This paper first introduces the concepts of smart grid and informatization system,and analyzes the importance of informatization system in smart grid.Then,the big data analysis and intelligent decision-making,the application of Internet of Things technology in power grid,and the application of artificial intelligence technology in power grid optimization are emphatically discussed.Subsequently,the security supporting measures of informatization system in smart grid are discussed.Finally,the challenges and future development trends of informatization system in smart grid are prospected,so as to provide reference for the development of smart grid informatization.