A Method for Determining Ethanol Content in Alcohol-Based Hand Sanitizer Under Non-Aqueous Media Conditions
In this paper,the ethanol content in alcohol-based hand sanitizer is determined and studied by gas chromatography under non-aqueous media conditions.This method uses isobutanol as the internal standard and N,N-dimethylformamide as the solvent,and the system suitability,precision,resolution of ethanol and impurities,and spike recovery rate of this method are studied.Commercially available alcohol-based hand sanitizers are also tested,and the spike recovery rate of ethanol is 99.4%.Practice has proved that this method has good feasibility,which can not only effectively protect the chromatographic column,prevent the loss of active ingredients,but also well separate ethanol from impurity peaks,and is suitable for the determination of ethanol content in alcohol-based hand sanitizer.
gas chromatographyethanolisobutanolN,N-dimethylformamide
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