As an important part of national innovation,improving regional innovation performance is of great significance in en-hancing the effectiveness of the national innovation system and supporting new breakthroughs in high-quality economic develop-ment.The intricate influence of network position on innovation performance has always been the focus of scholar's attention,and previous studies have found that network position has a facilitating,inhibiting and nonlinear relationship on innovation perform-ance.To bridge the gap between the theories,an attempt is made to deepen the understanding of the relationship between net-work position and differentiated knowledge base on regional innovation performance using the knowledge base view.For the net-work position theory,drawing on the knowledge base view literature that"heterogeneous knowledge is more valuable",we meas-ured the scale of knowledge value in the network from the perspective of heterogeneous knowledge and incorporated the knowledge value into the research framework of network position and regional innovation performance.For the theory of differentiated knowl-edge base,we constructed indicators of"differentiated knowledge base"based on the network perspective and the view of knowl-edge bases and established the"relevant"relationship with external knowledge to enrich the research on relevant diversification in differentiated knowledge base.Based on Chinese patent data,the panel negative binomial regression method was used to analyze the non-linear effects and interactions of network position and differentiated knowledge base on regional innovation performance.The study found that:(1)structural hole has a"U-shaped"curve relationship with regional innovation performance,and the interaction effect with differen-tiated knowledge base is significant;(2)centrality has an"inverted U-shaped"curve relationship with regional innovation per-formance,and the interaction effect with differentiated knowledge base is not significant;and(3)differentiated knowledge base positively promote regional innovation performance.The significant difference between the interaction effects of network position and differentiated knowledge base on regional innovation performance suggests that the impact of the value of resources acquired through network position on regional innovation performance cannot be ignored.The study has offered several insights.First,when formulating regional innovation policies,the government should consider the network position between regions and its impact on innovation performance.Encouraging interregional firms and academic in-stitutions to strengthen ties and moderately increase regional centrality in the network can enhance innovation.Second,the gov-ernment should view the differentiated knowledge base as a key driver of innovation.By diversifying the industrial structure and creating open innovation platforms,regions can integrate diverse knowledge and resources,thus boosting innovation.Lastly,a comprehensive innovation performance evaluation mechanism should be established.Monitoring and optimizing the network posi-tion and knowledge base can lead to overall regional innovation improvement.