过敏性紫癜患儿血清IgA型抗内皮细胞抗体与细胞间黏附分子-1相关性初探
Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch(o)nlein purpura
陈柏谕 1杨光路 1任少敏1
作者信息
- 1. 内蒙古医科大学附属医院儿科 内蒙古呼和浩特010059
- 折叠
摘要
目的 探讨过敏性紫癜(HSP)患儿血清IgA型抗内皮细胞抗体(IgA-AECA)与细胞间黏附分子-1(ICAM-1)水平及其相关性.方法 36例HSP患儿,其中26例无肾损害(HSP组),10例紫癜性肾炎(HSPN组),采用酶联免疫吸附法检测并比较血清IgA-AECA及ICAM-1的表达水平.结果 与HSP组相比,HSPN组IgA-AECA及ICAM-1的表达水平均显著增高,差异有统计学意义(P＜0.01);IgA-AECA与ICAM-1呈显著正相关(r=0.746,P＜0.01).结论 IgA-AECA可能作为HSP患儿ICAM-1高表达的始动因素,在疾病发展过程中起重要作用.
Abstract
Objectives To detect the levels of anti-endothelial cell IgA antibodies (IgA-AECA) and intercellular adhesion molecule-1 (ICAM-1) in children with Henoch-Sch(o)nlein purpura,and to analyze the correlation between IgAAECA and ICAM-1.Methods A total of 36 children with HSP were enrolled,26 without renal impairment (HSP group),and 10 with renal impairment (HSPN).The concentrations of IgA-AECA and ICAM-1 in serum were detected by enzyme linked immunosorbent assay (ELISA).Results The serum levels of IgA-AECA and ICAM-1 in HSPN group were significantly higher than those in HSP group (P＜0.01).The serum level of IgA-AECA showed positive correlation with the level of ICAM-1 (r=0.746,P＜0.01).Conclusions lgA-AECA may play an important role in the development of HSP and HSPN by up-regulating the express of ICAM-1.
关键词
过敏性紫癜/抗内皮细胞抗体/细胞间黏附分子-1/儿童Key words
Henoch-Sch(o)nlein purpura/anti-endothelial cell antibodies/intercellular adhesion molecule-1/child引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据