首页|脊髓性肌萎缩症患者脊柱矫形围手术期治疗药物管理

脊髓性肌萎缩症患者脊柱矫形围手术期治疗药物管理

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脊髓性肌萎缩症(SMA)是一种致命的遗传性神经肌肉罕见病,患者往往伴有不同程度的脊柱畸形.脊柱矫形手术作为改善脊柱畸形的常用手段,其风险较高,可能会引发感染、出血、神经损伤等并发症.鉴于这些风险,合理的围手术期用药对于控制合并症以及促进患者康复至关重要.然而,由于特殊的生理病理状态且缺乏统一的标准规范,SMA患者脊柱矫形围手术期的药物治疗管理面临诸多挑战.现本文对SMA患者脊柱矫形围手术期的药物治疗管理进行综述,旨在为临床提供循证依据和合理用药参考.
Medication therapy management of patients with spinal muscular atrophy during the perioperative period of scoliosis correction surgery
Spinal muscular atrophy(SMA),a devastating hereditary neuromuscular disease,is often complicated by scoliosis.While scoliosis correction surgery is frequently indicated to correct spinal deformities,it is not without significant risks,including the potential for infection,hemorrhage,and neurological damage.Consequently,the management of perioperative medications is of paramount importance for the prevention and control of these complications,as well as for facilitating patient recovery.However,the distinctive physiological and pathological characteristics of SMA,coupled with the lack of standardized protocols,present considerable challenges in perioperative medication management.This review article offers an in-depth examination of the perioperative medication therapy management for patients with SMA undergoing scoliosis surgery.It aims to establish an evidence-based framework and provide a reference for the judicious use of drugs in clinical settings.

spinal muscular atrophyscoliosis correction surgeryperioperative periodmedication therapy management

幸小东、刘艳、刘昕竹、蒋文高、张健

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重庆医科大学药学院(重庆 400016)

上海交通大学医学院附属新华医院临床药学部(上海 200092)

脊髓性肌萎缩症 脊柱矫形术 围手术期 治疗药物管理

2025

临床儿科杂志
上海市儿科医学研究所 上海交通大学医学院附属新华医院

临床儿科杂志

北大核心
影响因子:1.486
ISSN:1000-3606
年,卷(期):2025.43(1)