Status of cognitive impairment in survivors of acute respiratory failure treated with ECMO and analysis of its influencing factors
Objective To investigate the status of cognitive impairment in survivors of acute respiratory fail-ure(ARF)treated with extracorporeal membrane oxygenation(ECMO)and to analyze the influencing factors in order to provide reference for screening high-risk population of cognitive impairment and its prevention and treatment in these survivors.Methods 136 survivors of ARF treated with ECMO were collected,and their cognitive function were evaluated.The proportion of cognitive dysfunction was investigated.Logistic regression analysis was used to ana-lyze the influencing factors of cognitive dysfunction in survivors of ARF treated with ECMO.Results The proportion of cognitive dysfunction among survivors of ARF treated with ECMO at discharge,3 months,6 months and 1 year af-ter discharge was 64.7％,50.7％,44.1％and 38.2％,respectively.Logistic regression analysis showed that acute physiology and chronic health status score Ⅱ(APACHE Ⅱ score,OR=1.782),sequential organ failure score(SO-FA score,OR=1.665),ECMO treatment time(OR=2.321)and delirium(OR=5.876)were risk factors for cog-nitive dysfunction in survivors of ARF treated with ECMO 1 year after discharge(P＜0.05).Conclusion The pro-portion of cognitive dysfunction among survivors of ARF treated with ECMO gradually decreased within one year after discharge,but a large proportion of survivors still faced long-term cognitive dysfunction.APACHE Ⅱ score,SOFA score,ECMO treatment time and delirium are risk factors for long-term cognitive dysfunction faced by these survivors.High risk populations with these characteristics can be screened clinically and targeted interventions can be given.
万方数据
维普
