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成人肺炎支原体肺炎的危险因素分析及预测模型构建

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目的 分析成人肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)的危险因素并构建其发生的预测模型。方法 严格根据纳入排除标准选取2023年1-12月六安市人民医院呼吸与危重症医学科收治的社区获得性肺炎(Community acquired pneumonia,CAP)的患者,并对患者临床资料进行分析。所有研究对象经R语言Sample函数7∶3随机划分为训练集和验证集,采用单因素和多因素Logistic回归分析筛选成人MPP的独立预测因子,并建立列线图模型。应用受试者工作特征(ROC)曲线、校准曲线、决策曲线分析(DCA)曲线对模型进行评价和验证。结果 以年龄、最高体温、畏寒、干咳、CRP、NLR、树芽征7项独立预测因子所构建的列线图具有较高的准确性,训练集的ROC曲线下面积为AUC=0。900(95%CI:0。863,0。936),验证集ROC曲线下面积为AUC=0。878(95%CI:0。812,0。944)。且训练集和验证集的校准曲线拟合良好,训练集、验证集分别在0。05和0。94、0。09和0。82的风险阈值概率范围内,模型具有净获益。结论 7项独立预测因子所构建的列线图预测模型在预测成人MPP的发生、帮助临床医生及早识别高危患者并制定有效的诊疗方案存在一定的指导意义。
Risk factors analysis and prediction model construction of Mycoplasma pneumoniae pneumonia in adults
Objective To analyze the risk factors of Mycoplasma pneumoniae pneumonia(MPP)in adults,and to construct a predictive model for its occurrence.Methods Patients with Community-Acquired Pneumonia(CAP)admitted to the Department of Respiratory and Critical Care Medicine of Lu'an People's Hospital from Janu-ary to December 2023 were selected strictly according to the inclusion and exclusion criteria,and the clinical data of the patients were analyzed.All subjects were randomly divided into training sets and validation sets by R language sample function 7∶3.Univariate and multivariate Logistic regression analysis was used to screen independent predic-tors of adult MPP,and a nomogram model was established.The receiver operating characteristic(ROC)curve,cali-bration curve,and decision curve analysis(DCA)curve were used to evaluate and verify the model.Results The nomogram constructed by 7 independent predictors of age,body temperature,chills,dry cough,CRP,NLR,and the tree-in-bud sign had high accuracy.The area under the ROC curve of the training set was AUC=0.900(95%CI:0.863,0.936),and the area under the ROC curve of the validation set was AUC=0.878(95%CI:0.812,0.944).The calibration curves of the training set and the verification set were well-fitted.The training set and the verification set were within the risk threshold probability range of 0.05 and 0.94,0.09,and 0.82,respectively,the model had a net benefit.Conclusion The nomogram prediction model constructed by seven independent predictors has certain guiding significance in predicting the occurrence of adult MPP,helping clinicians to identify high-risk pa-tients early and formulate effective diagnosis and treatment plans.

AdultMycoplasma pneumoniae pneumoniaRisk factorsPrediction model

崔颜、叶永青

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233030 安徽蚌埠,蚌埠医科大学研究生院

237000 安徽六安,安徽医科大学附属六安医院(六安市人民医院)呼吸与危重症医学科

成人 肺炎支原体肺炎 危险因素 预测模型

2025

临床肺科杂志
安徽医科大学 解放军第105医院

临床肺科杂志

影响因子:1.42
ISSN:1009-6663
年,卷(期):2025.30(1)