MFluoroquinolones resistance and adverse reactions of anti-tuberculosis drugs in 280 patients with multi-drug resistant tuberculosis
Objective To analyze the situation of fluoroquinolone resistance and the adverse reactions of an-ti-tuberculosis drugs in multidrug-resistant tuberculosis.Methods The clinical data of 280 cases of MDR-TB diag-nosed and treated in Chengdu Public Health Clinical Medical Center from May 2020 to June 2022 were collected,and the fluoroquinolones resistance and anti-tuberculosis drug adverse reactions of MDR-TB patients were analyzed.Re-sults 1.The 280 MDR-TB patients tended to be younger,and the drug resistance spectrum of HRSm,HR+flu-oroquinolone-resistant combination was the most common.The drug resistance rates of Ofx,Lfx,and Mfx in retreated patients were 40.3％,35.9％and 37.9％higher than those in initially treated patients(21.6％,22.9％,and 24.3％,and the difference was statistically significant(x2=8.303,P=0.004;x2=4.162,P=0.041;x2=4.430,P=0.035).2.The incidence of extrapulmonary tuberculosis in MDR-TB was the most common in tubercu-lous pleurisy(30.7％)and bronchial tuberculosis(25.4％),while tuberculous meningitis(2.1％)was rare.3.The top 3 cases of adverse drug reactions during the treatment of MDR-TB were hyperuricemia(55.7％),liver func-tion injury(38.9％)and thyroid dysfunction(12.9％),and there were significant differences in hyperuricemia,liver function injury,thyroid dysfunction and mental system between primary and retreatment patients(x2=6.340,P=0.012;x2=3.977,P=0.046;x2=6.957,P=0.008;x2=6.283,P=0.012).4.280 cases of MDR-resistant patients had a success rate of 68.9％and a cure rate of 59.6％,of which the cure rate was 67.6％in the initial treatment group and 56.8％in the re-treatment group.Conclusion The situation of multidrug-resistant tuberculosis in Sichuan is serious,the incidence tends to be younger,and the resistance rate of fluoroquinolones in retreated patients is significantly higher than that of initial treatment.The monitoring of fluoroquinolone resistance should be paid attention to in clinical treatment.The incidence of adverse reactions in the anti-tuberculosis process of multi-drug resistant tuberculosis is high,and attention should be paid to the monitoring and treatment of adverse reactions to en-sure the treatment effect of patients.
multidrug resistancetuberculosisfluoroquinolonesadverse drug reactions
万方数据
维普
