Objective This study aims to investigate hemodynamic alterations in saccular intracranial aneurysms and their adjacent arteries using four-dimensional flow magnetic resonance imaging(4D-FLOW MRI).Methods We enrolled 68 patients diagnosed with intracranial aneurysms through CT angiography and head MR angiography at Wuhan Union Hos-pital.Hemodynamic analyses were conducted after 4D-FLOW MRI scanning and reconstruction,and the hemodynamic pa-rameters were automatically derived through the manual delineation of vessel contours at various critical locations within the parent artery.These locations included the aneurysm inlet cross-section,the aneurysm's largest cross-section in alignment with the blood flow direction,the aneurysm outlet cross-section,and symmetrical positions corresponding to the contralateral arteries.Paired-sample t-test was employed to compare hemodynamic parameters between the parent artery and the contra-lateral artery.According to the grouping based on the maximum diameter and size ratio(SR)of saccular aneurysms,an in-dependent sample t-test was employed to analyze the differences in hemodynamic parameters of the parent arteries among different groups.Results In the parent artery compared with the contralateral artery,the maximum WSS,mean WSS,and maximum axial WSS-maximum circumferential WSS at the entrance of the intracranial aneurysm were smaller than those in the contralateral symmetrical cross section;the maximum WSS,mean WSS,mean axial WSS,and mean axial WSS-maximum circumferential WSS at the largest cross section of the aneurysm along the direction of blood flow were smaller in the parent artery,and maximum energy loss and mean energy loss were significantly higher in the contralateral arteries,and all these differences were statistically significant(P＜0.05).In the parent arteries,the maximum axial WSS and mean axial WSS of the aneurysm inlet section was bigger in the group with a maximum diameter of＞5 mm than in the group with a maximum diameter of ≤5 mm,and the mean axial WSS of the aneurysm inlet section was greater in the SR＞2 group compared with that of the SR ≤2 group,and the differences between the groups were statistically significant(P＜0.05).Conclusion The application of 4D-FLOW MRI can dynamically display the flow environment in the intracranial saccular aneurysm and the parent artery around the aneurysm neck,and quantitatively evaluate the hemodynamic characteristics,which is of great value in exploring the formation factors of intracranial saccular aneurysms.
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