Objective To evaluate the efficacy of CT perfusion imaging(CTP)for patients with moyamoya disease who underwent revascularization.Methods Twenty-eight patients with moyamoya disease underwent cerebral revascularization(superficial temporal artery-middle cerebral artery bypass graft combined with brain-dura-temporalis muscle grafting).CTP examination was performed before and after operation.The absolute value of intraoperative perfusion parameters and the rel-ative value of intraoperative and contralateral mirror perfusion parameters were measured and compared before and after sur-gery.Cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT)and time to peak(TTP)were compared and analyzed.Results The bridging vessels of 28 patients with moyamoya disease showed patency.There were significant differences in postoperative perfusion parameters of CBF(temporal lobe and parietal lobe),CBV(frontal lobe,temporal lobe,parietal lobe),MTT(parietal lobe)and TTP(frontal lobe,temporal lobe,parietal lobe)(P＜0.05).There were significant differences in rCBF(temporal lobe),rMTT(parietal lobe)and rTTP(parietal lobe)in the mirror control area(P＜0.05).Conclusion After surgical intervention,CBF revascularization was improved in MMD patients,espe-cially in patients with severe perfusion impairment.Therefore,CT perfusion imaging can not only reflect the functional ima-ging of brain microcirculation information,but also help to judge the location,severity,surgical side and surgical method of MMD cerebral ischemia.It can also quickly understand whether the postoperative ischemia is improved,and can be used as an important examination method to test the efficacy of surgery.
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维普
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