Objective Quantitative CT was used to analyze the correlation between pulmonary vascular changes,emphy-sema and airway restriction in COPD patients,and confirm the correlation between pulmonary vascular and emphysema ab-normalities in COPD patients in vivo.Methods A total of 113 patients with chronic obstructive pulmonary disease(COPD)on the digital Lung platform were retrospectively analyzed.The percentage of lung low attenuation area(LAA％),total lung and the percentage of pulmonary vessel volume in each lobe(IPVV％)were calculated on inspiratory phase CT images.Differences in pulmonary vascular parameters of different severities of emphysema were compared using one-way ANOVA(normal distribution)or Kruskal Wallis H rank-sum test(non-normal distribution).Spearman correlation analysis of the correlation between IPVV％and LAA％and FEV1％and FEV1/FVC.Results The IPVV％of the whole lung and each lung lobe were significantly negatively correlated with LAA％(P＜0.001).The strongest correlation coefficient was r=-0.735.The strongest correlations were found in the right upper lobe and left upper lobe.The whole lung and each lobe of IPVV％were significantly positively correlated with FEV1％and FEV1/FVC(all P＜0.001),and the strongest correla-tion coefficients were r=0.441 and r=0.498,respectively.The correlation between IPVV％and LAA％was significantly stronger than that between IPVV％and FEV1％and FEV1/FVC.Conclusion IPVV％was associated with emphysema severity and pulmonary function outcomes,and the correlation with emphysema was stronger than that with lung function,confirming the association between pulmonary vascular alterations in COPD and changes in emphysema.
NETL
NSTL
维普
万方数据
