基于定量CT分析COPD患者肺血管改变与肺气肿严重程度的一致性
Quantitative CT Was Used to Analyze the Consistency between Pulmonary Vascular Changes and Emphysema Severity in COPD Patients
谷慧慧 1韩婷婷 2曹宪宪 3高小燕 4郭佑民 2金晨望5
作者信息
- 1. 712046 咸阳,陕西中医药大学
- 2. 710061 西安交通大学第一附属医院医学影像科
- 3. 100021 国家癌症中心/国家肿瘤临床研究中心/中国医学科学院北京协和医学院肿瘤医院
- 4. 710068 西安,陕西省人民医院CT室
- 5. 712046 咸阳,陕西中医药大学;710061 西安交通大学第一附属医院医学影像科
- 折叠
摘要
目的 基于定量电子计算机断层扫描(CT)分析慢性阻塞性肺疾病(COPD)患者肺血管改变、肺气肿、气道受限三者相关性,在体内证实COPD患者肺血管与肺气肿异常的相关性.方法 回顾性分析"数字肺"平台2015年3月至2016年11月慢性阻塞性肺疾病患者(COPD)共计113例.计算吸气相CT图像上肺低衰减区百分比(LAA％),全肺以及各个肺叶肺血管体积百分比(IPVV％).采用单因素方差分析(正态分布)或Kruskal Wallis H秩和检验(非正态分布)比较不同严重程度肺气肿的肺血管参数的差异.Spearman相关分析IPVV％与LAA％和一秒用力呼气容积(FEV1)/用力肺活量(FVC)、FEV1％的相关性.结果 全肺以及各个肺叶IPVV％与LAA％呈显著强负相关(P值均＜0.001),最强相关系数r＝-0.735,在右肺上叶和左肺上叶相关性最强.全肺以及各个肺叶IPVV％与FEV1％和FEV1/FVC均呈显著正相关(P值均＜0.001),最强相关系数分别为r=0.441和r=0.498.IPVV％与LAA％的相关性显著强于IPVV％与FEV1％和FEV1/FVC的相关性.结论 IPVV％与肺气肿严重程度和肺功能结果之间具有相关性,IPVV％与肺气肿的相关性强于IPVV％与肺功能的相关性,在体内证实了COPD肺血管改变与肺气肿变化之间的联系.
Abstract
Objective Quantitative CT was used to analyze the correlation between pulmonary vascular changes,emphy-sema and airway restriction in COPD patients,and confirm the correlation between pulmonary vascular and emphysema ab-normalities in COPD patients in vivo.Methods A total of 113 patients with chronic obstructive pulmonary disease(COPD)on the digital Lung platform were retrospectively analyzed.The percentage of lung low attenuation area(LAA％),total lung and the percentage of pulmonary vessel volume in each lobe(IPVV％)were calculated on inspiratory phase CT images.Differences in pulmonary vascular parameters of different severities of emphysema were compared using one-way ANOVA(normal distribution)or Kruskal Wallis H rank-sum test(non-normal distribution).Spearman correlation analysis of the correlation between IPVV％and LAA％and FEV1％and FEV1/FVC.Results The IPVV％of the whole lung and each lung lobe were significantly negatively correlated with LAA％(P＜0.001).The strongest correlation coefficient was r=-0.735.The strongest correlations were found in the right upper lobe and left upper lobe.The whole lung and each lobe of IPVV％were significantly positively correlated with FEV1％and FEV1/FVC(all P＜0.001),and the strongest correla-tion coefficients were r=0.441 and r=0.498,respectively.The correlation between IPVV％and LAA％was significantly stronger than that between IPVV％and FEV1％and FEV1/FVC.Conclusion IPVV％was associated with emphysema severity and pulmonary function outcomes,and the correlation with emphysema was stronger than that with lung function,confirming the association between pulmonary vascular alterations in COPD and changes in emphysema.
关键词
慢性阻塞性肺疾病/肺血管/肺气肿/定量CTKey words
Chronic obstructive pulmonary disease/Pulmonary vascular/Emphysema/Quantitative引用本文复制引用
基金项目
国家卫生健康委能力建设和继续教育中心放射影像数据库建设项目(YXFSC2022JJSJ002)
出版年
2024
NETL
NSTL
维普
万方数据