sBTFE序列在体内正常胎脑和异质性改变胎脑的应用研究
The Heterogeneous Alteration in Normal Fetal Brain in Vivo and in Utero Revealed by sBTFE Sequence
李茗 1李想 1胡安宁 1陆芳菲 1薛巽文 1蒋雯欣 1韩小伟 1费强1
作者信息
- 1. 210008 南京大学医学院附属鼓楼医院医学影像科
- 折叠
摘要
目的 探讨具有灵敏度编码的快速平衡稳态梯度场回波(sBTFE)序列对测量胎脑白质信号强度(SI)及胎脑白质改变中的应用价值.方法 对160例在21～39孕周的异质性胎脑进行sBTFE序列1.5T扫描.根据胎龄将胎儿大脑分为4组(A～D组),分别计算每个胎龄组双侧前额叶、枕叶、颞叶、顶叶和中央前白质区以及丘脑、小脑和脑桥的信号强度比值(SIRs),并用方差分析方法对上述感兴趣内SIRs的组间差异进行评估.结果 sBT-FE具有良好的脑脊液白质对比度和较高的空间分辨率,对胎脑白质的成像具有最佳的诊断信度(3.35±0.42).结论 sBTFE序列显示了胎脑白质SIR随胎龄的不同而不同,反映了生发基质何时何地迁移以及髓鞘形成过程的时间顺序.
Abstract
Objective To explore the application value of the fast balanced steady-state gradient field echo(sBTFE)sequence with sensitivity coding for measuring the signal intensity(SI)and fetal white matter changes.Methods A sBT-FE sequence 1.5T scan was performed on 160 heterogeneous fetal brains at 21 to 39 weeks of gestation.Fetal brains were divided into four groups of A-D according to gestational age,calculated signal intensity ratios(SIRs)for bilateral prefron-tal,occipital,temporal,parietal and parietal precentral white matter regions,thalamus,cerebellum and pons for each gesta-tional age group,and group differences in SIRs of interest were assessed by ANOVA.Results The sBTFE has good CSF white matter contrast and high spatial resolution,providing optimal diagnostic reliability for imaging the fetal brain white matter(3.35±0.42).Conclusion The sBTFE sequence shows that the fetal brain white matter SIR varies with gesta-tional age,reflecting when and where the germinal matrix migrated and the temporal order of the myelination process.
关键词
活体胎儿颅脑成像/白质改变/信号强度比/快速平衡稳态梯度场回波/脑内连通性Key words
In vivo fetal brain imaging/White matter alteration/Signal intensity ratio/Balanced turbo field echo se-quence/Brain inter-connectivity引用本文复制引用
基金项目
国家自然科学基金项目(81720108022)
国家自然科学基金项目(91649116)
南京市医学科技发展资金项目(YKK16112)
出版年
2024
NETL
NSTL
维普
万方数据