腰骶丛MRN在腓骨肌萎缩症1A评估中的作用及表现分析
Utility of Lumbosacral Plexus MR Neurography in the Assessment of Charcot-Marie-Tooth Disease 1A and Imaging Feature Analysis
孙兴文 1周广金 1刘小璇 2朱雨辰 2樊东升 2袁慧书 1张立华1
作者信息
- 1. 100191 北京大学第三医院放射科
- 2. 100191 北京大学第三医院神经内科
- 折叠
摘要
目的 探讨腓骨肌萎缩症(CMT)1A的腰骶丛神经影像的表现并分析神经成像在该病评估及诊断中的应用价值.方法 对46例临床确诊的CMT1A患者的腰骶丛神经成像进行分析,分析神经形态、信号特点并测定脊神经L4、5,股神经及坐骨神经的直径与正常组进行比较,并与电生理、临床特征及评分进行相关性分析.结果 受累神经主要表现为双侧对称性增粗(93.5％),高达65.2％的表现为中等程度以上的增粗;67.4％增粗的神经在T2WI脂肪抑制序列伴信号增高;增粗神经周围26.1％可伴囊肿形成;23.9％伴马尾神经增粗;神经直径与电生理、临床评分以及肌力存在显著相关性.结论 腰骶丛神经成像可准确评估CMT1A的周围神经的形态及信号特点,可用于临床诊断及评估.
Abstract
Objective To investigate MR neurography features of Charcot-Marie-Tooth Disease type 1A(CMT1A)and analyze the value of MR neurography in the diagnosis and assessment of the disease.Methods We analyzed the MR neu-rography features of 46 CMT1A cases.The morphology,signal intensity and nerve diameter of L4 5 nerve roots,the femoral nerve,and the sciatic nerve were assessed and compared with healthy controls.Correlations of nerve diameter with electro-physiological results,clinical variables and scores were analyzed.Results The affected nerves mainly presented as sym-metric thickening(43,93.5％).65.2％cases showed moderate to prominent nerve thickening.The signal intensity in fat-suppressed T2 imaging was increased in 67.4％of the thickened nerves.26.1％of the thickened nerves were accompanied by perineural cyst formation.23.9％of the cases showed thickening of the cauda equina.Significant correlations were ob-served between nerve diameters and electrophysiological results,clinical variables and scores.Conclusion Lumbosacral plexus MR neurography could accurately assess the morphological features and signal changesof affected nerves in CMT1A.It could be used for clinical diagnosis and assessment of the disease.
关键词
周围神经成像/腓骨肌萎缩症/磁共振成像Key words
Peripheral nerve imaging/Charcot-marie-tooth disease/Magnetic resonanc imaging引用本文复制引用
出版年
2024
NETL
NSTL
万方数据