Objective To investigate MR neurography features of Charcot-Marie-Tooth Disease type 1A(CMT1A)and analyze the value of MR neurography in the diagnosis and assessment of the disease.Methods We analyzed the MR neu-rography features of 46 CMT1A cases.The morphology,signal intensity and nerve diameter of L4 5 nerve roots,the femoral nerve,and the sciatic nerve were assessed and compared with healthy controls.Correlations of nerve diameter with electro-physiological results,clinical variables and scores were analyzed.Results The affected nerves mainly presented as sym-metric thickening(43,93.5％).65.2％cases showed moderate to prominent nerve thickening.The signal intensity in fat-suppressed T2 imaging was increased in 67.4％of the thickened nerves.26.1％of the thickened nerves were accompanied by perineural cyst formation.23.9％of the cases showed thickening of the cauda equina.Significant correlations were ob-served between nerve diameters and electrophysiological results,clinical variables and scores.Conclusion Lumbosacral plexus MR neurography could accurately assess the morphological features and signal changesof affected nerves in CMT1A.It could be used for clinical diagnosis and assessment of the disease.
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