Objective To explore the imaging and pathological features of astroblastoma.Methods The clinical,ima-ging and pathological data of 12 patients with astroblastoma were retrospectively analyzed and their characteristics were sum-marized.Results All the 12 cases of astroblastoma were located in the supratentorial and near the brain margin,with clear boundaries,the maximum diameter range of the tumor was 2.0-8.2 cm,and the median was 5.45 cm.There were 2 cases of cystic lumps with nodules(1 nodule was located in the central area of the mass,and 1 nodule was located in the marginal area of the mass).The remaining 10 cases of multiple intra tumoral cysts typically with bubbly appearance,there were multi-ple microcystic foci in the solid part and multiple large cystic foci at the margins;5 cases were accompanied by spot-like cal-cification.CT imaging showed hypodense lesion than normal brain parenchyma,and the cystic part showed low density.The solid part of astroblastoma showed equal or slightly lower signal on T1WI and equal or higher signal on T2WI,and the cystic part showed low signal on T1 WI and high signal on T2WI.The enhanced imaging showed markedly enhanced solid mass with some enhanced cystic wall.The distribution of tumor cells around small blood vessels to form pseudochrysanthemum-shaped clusters or papillary structures on optical microscope,with thick and short cell protrusions,and nuclei distributed away from the side of hyaluromorphosis vessels.Immunohistochemistry with positive staining:GFAP(11/12),Vimentin(9/12),Syn(2/12),S-100(9/11),Olig-2(6/10),EMA(5/7),CD34(1/6),ATRX(2/5);The positive index of Ki-67 in 7 cases of low-grade astroblastoma was 1％-21％,with average of 7.7％,and 5 cases of high-grade astroblastoma was 15％-28％,with average of 27.8％,respectively.5 molecular genetics examination showed IDH1/2(-).Conclusion Astroblastoma is a rare neuroepithelial tumor with uncertain origin,no specific in clinical symptoms while characteristic radiographic fea-tures.It is usually large,well-delineated and frequently occurs insupratentorial regions above the tentum cerebellum.On ima-ging,astroblastoma shows solid mass with cysts,punctate calcification may present.The cystic part of the mass shows a bub-bly appearance,with significantly contrast enhancing and little vasogenic edema.However,the final diagnosis still depends on the histopathological examination.
AstroblastomaImaging featuresPathological features
NETL
NSTL
万方数据
