Objective To investigate the clinicopathological and imaging features of infants Kaposiform hemangioendothe-lioma(KHE).Methods The clinicopathological and imaging data of 8 children with KHE confirmed by pathology from July 2017 to April 2022 were retrospectively analyzed,including 8 cases with plain and enhanced CT scans,and 3 cases with plain and enhanced MRI scans.Results All clinically showed subcutaneous tumors,5 cases were accompanied by abnormal skin color,and 7 cases were combined with Kasabach-Merritt phenomenon(KMP).The imaging showed a single tumor,5 cases lo-cated in trunk,2 cases in head and neck,l case in trunk and neck,with a median diameter of 8.3 cm,7 cases of solid central mass with surrounding infifiltrative portions,and 1 case of infifiltrative lesion without defifined areas of solidity.There were 5 cases of mixed type,and 3 cases of deep type;CT plain scan mainly showed equal and slightly low density,7 cases showed heterogeneous obvious enhancement,and 1 case showed heterogeneous mild enhancement;MRI plain scan T1WI showed iso-intensity and low-intensity,T2 WI fat-suppressed mainly hyper-intensity,accompanied by banded and spot-like low-intensity T1WI fat-suppressed enhancement showed heterogeneous and obvious enhancement;6 cases of bone destruction,5 cases of peritumoral soft tissue reticular lymphedema,pleural effusion in 4 cases,local skin thickening in 2 cases.Microscopeshowed o-val or spindle-shaped endothelial cells and capillaries were nest-like hyperplasia,resembling"glomeruli",immunohistochemis-tryshowed CD31 and CD34 were positive,GLUT-1 were negative,and some ERG and D2-40 positive.Conclusion Infants KHE has certain clinical and imaging features,and the diagnosis still needs histopathological support.
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