Objective To evaluate Cube FLAIR enhanced T2 WI scanning sequences for early and accurate identifica-tion of patients with non-small cell lung cancer(NSCLC)after EGFR-TKIs.Methods 23 patients with lung cancer diag-nosed pathologically and with LM after targeted drug therapy were examined by enhanced T1 WI,sagittal Cube T1 WI and sagittal Cube FLAIR T2 WI.The scanned images obtained were analyzed by two MRI diagnostic physicians who analyze the images in a blind way,respectively.The evaluation contents included enhancement or not,lesion site(including supraten-torial superficial brain area,subtentorial cerebellar brainstem area and whole brain area),and image quality evaluation(qualitative evaluation and quantitative evaluation).Results Enhanced T1 WI,sagittal Cube T1 WI and sagittal Cube FLAIR T2 WI were successfully performed in all 23 cases.The images obtained could be used for quality evaluation.Com-pared with enhanced Cube T1 WI,2 cases of superficial lesions were not detected(χ2 =27.74,P =0.02),compared with enhanced Cube FLAIR T2 WI,1 case of superficial lesion was not detected,and1 case of whole brain lesion was not detected(χ2 =26.56,P =0.01).CR of the enhanced T1 WI image was lower than that of the enhanced Cube T1 WI image(t =-0.44,P<0.05),and CNR of the enhanced T1 WI image was equal to that of the enhanced Cube T1 WI image(t =-2.49,P<0.05).CR in enhanced T1 WI images was lower than that in enhanced Cube FLAIR T2 WI images(t =-0.15,P<0.05).CR in enhanced Cube T1WI images was lower than that in enhanced Cube FLAIR T2WI images(t =-0.26,P<0.05).The image quality of enhanced T1 WI was 2 points in 1 case,3 points in 20 cases and 4 points in 2 ca-ses.Cube T1WI image quality was rated 3 points in 4 cases and 4 points in 19 cases(T-value =1.38,P =0.03).En-hanced Cube FLAIR T2WI sequence image quality was 3 points in 4 cases and 4 points in 19 cases(T-value =1.26,P = 0.02).Conclusion Enhanced Cube FLAIR T2 WI images,as volume scanning,have high resolution,and are highly sensi-tive to new LMS in NSCLC patients treated with EGFR + after EGFR-TKIs,providing evidence for follow-up observation and individualized treatment of lung cancer patients with targeted therapy.
NETL
NSTL
万方数据
