首页|基于定量CT诺模图对支气管扩张咯血风险的预测研究

基于定量CT诺模图对支气管扩张咯血风险的预测研究

Prediction of the Bronchiectasis Hemoptysis Based on Nomogram of Quantitative CT

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目的 建立和验证基于定量CT建立的诺模图以预测支气管扩张咯血发生的风险.方法 回顾性搜集233 例支气管扩张患者的一般资料及定量CT指标,采用分层随机抽样方式按照6∶ 4 比例分为训练集(n =133)和验证集(n =100),根据2 年内随访有无发生咯血分为两组.在训练集中通过多因素逐步Logistic回归以确定支气管扩张咯血发生的独立危险因素,构建诺模图;并使用校准曲线评价模型的拟合优度,采用受试者工作特征(ROC)曲线评价模型的预测效能,并采用决策曲线分析评价模型的临床应用价值.结果 多因素Logistic回归结果显示吸烟史、累及支气管总支数、最大扩张支气管横截面积、最大扩张支气管扩张程度是支气管扩张咯血发生的独立危险因素.诺模图在训练集和验证集中均显示出良好的校准和区分能力,ROC 曲线下面积在训练集中为 0.951(95%CI:0.914~0.989),在验证集中为0.956(95%CI:0.918~0.994).决策曲线分析表明其具有临床实用价值.结论 基于定量CT构建的诺模图具有良好的临床预测效能,并得到了可靠验证.
Objective To establish and verify a nomogram based on quantitative CT for predicting the risk of bronchiec-tasis hemoptysis.Methods The general and quantitative CT indexes of 233 patients with bronchiectasis were collected retrospectively.Stratified random sampling was used to divide patients into training group(n = 133)and verification group(n = 100)according to ratio of 6∶ 4,and patients were divided into two groups according to the occurrence of hemoptysis during the follow-up within 2 years.In the training group,the independent risk factors of bronchiectasis hemoptysis were de-termined by multi-factor stepwise Logistic regression,and the nomogram was constructed.The calibration curve was used to evaluate the goodness of fit of the model,the receiver operating characteristic(ROC)curve was used to evaluate the predic-tive efficiency of the model,and the decision curve analysis(DCA)was used to evaluate the clinical application value of the model.Results Multivariate Logistic regression results showed that smoking history,the total number of involved bron-chus,the cross-sectional area of the most severely dilated bronchus,the degree of the most severely dilated bronchus were independent risk factors for bronchiectasis hemoptysis.Nomogram showed good calibration and differentiation ability with the area under the curve(AUC)of 0.951(95% CI:0.914-0.989)in the training group and 0.956(95% CI:0.918-0.994)in the verificationgroup.Theanalysisofdecisioncurve(DCA)showedthattherewasofclinicalpracticalvaluein the nomogram model.Conclusion The nomogram constructed based on quantitative CT has good clinical predictive effi-cacy and has been verified reliably.

BronchiectasisHemoptysisQuantitative CTNomogram

阴玮灵、黄晓旗、王雷、任涛、王明全、郭佑民

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716000 延安大学附属医院影像中心

710000 西安交通大学第一附属医院放射科

支气管扩张 咯血 定量CT 诺模图

2024

临床放射学杂志
黄石市医学科技情报所

临床放射学杂志

CSTPCD北大核心
影响因子:0.872
ISSN:1001-9324
年,卷(期):2024.43(3)
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