Objective To investigate the feasibility of amide proton transfer(APT)magnetic resonance imaging in the diagnosis of obstructive sleep apnea(OSA).Methods A total of 13 patients with obstructive apnea who received treat-ment and 20 normal control patients with gender and age matching were prospectively collected.Clinical data analysis and clinical psychology scale assessment were performed on the two groups respectively.Conventional magnetic resonance ima-ging and amide proton transfer imaging were performed for each brain region of interest.The asymmetric magnetic transfer rateofamideproton(MTRasym)at3.5 ppmineachbrainregionofinterestwascalculated.Thedifference of MTRasym(3.5 ppm)between two groups in different brain regions was compared.The correlation between MTRasym(3.5 ppm)and Epworth ESS score in each brain region was analyzed.Results Compared with control group,MTRasym(3.5 ppm)of bi-lateral hippocampus,left caudate nucleus and left temporal lobe white matter in OSA group was increased,with statistical significance(all P<0.05),while MTRasym(3.5 ppm)of residual brain area was not statistically significant between the two groups(P>0.05),MTRasym(3.5 ppm)of left lentulous nucleus and left hippocampus was positively correlated with ESS score(r =0.863,P =0.007;r =0.707,P = 0.037).Conclusion APT magnetic resonance imaging technology found that MTRasym(3.5 ppm)increased in bilateral hippocampus,left caudate nucleus and left temporal lobe white mat-ter in OSA patients,and MTRasym(3.5 ppm)in left lentate nucleus and left hippocampus was correlated with ESS score.It was suggested that APT magnetic resonance imaging might provide diagnostic basis for early metabolic changes in OSA patients.
Obstructive sleep apneaMagnetic resonance imagingAmide proton transfer
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