Objective This study aimed to explore the diagnostic value of pre-contrast T1 mapping combined with diffu-sion-weighted imaging(DWI)in magnetic resonance imaging(MRI)for breast lesion assessment.Methods A prospec-tive continuous collection of MR images was conducted on 44 female patients with breast lesions.Two radiologists independ-ently delineated regions of interest for each lesion and analyzed T1 values and apparent diffusion coefficient(ADC)values.Intra-class correlation coefficients(ICC)were used to assess inter-observer consistency.Comparative evaluations were per-formed for three assessment methods(T1 values,ADC values,and T1 + ADC values)regarding their diagnostic efficacy in distinguishing between benign and malignant breast lesions.Receiver operating characteristic(ROC)curves,area under the curve(AUC),specificity,and sensitivity were calculated.Spearman analysis was employed to assess the correlation between T1 values and breast cancer pathological features.Results A total of 44 patients with 50 lesions(17 benign,33 malig-nant)were included in the breast MRI analysis.Significant differences in ADC values and T1 values were observed between the benign and malignant groups(P<0.001).T1 + ADC values demonstrated optimal diagnostic efficacy with an AUC of 0.989.T1 values showed a significant negative correlation and statistical difference with axillary lymph node metastasis sta-tus(r =-0.472,P<0.01).Conclusion Pre-contrast T1 mapping have the potential to differentiate between benign and malignant breast lesions,and the combined use of T1 values and ADC values further enhances diagnostic accuracy.
Breast lesionMagnetic resonance imagingT1 mappingDiffusion weighted image
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