Objective To compare single-dose gadobutrol with single-dose gadopentetate dimeglumine in the cardiac late gadolinium enhancement magnetic resonance imaging(MRI)on heart failure patients to examine infarcted myocardi-um.Methods A prospective selection of 42 myocardial infarction patients with heart failure who had undergo cardiac late gadolinium enhancement MRI were randomly divided into two groups according to different type of contrast agents:group A(gadopentetate dimeglumine)and group B(gadobutrol).Finally,cardiac magnetic resonance images of 40 patients were used for data analysis:20 in group A and 20 in group B.Following the administration,the late gadolinium enhancement ima-ges were acquired5-8 mins,9-12 mins and 13-16 mins later,respectively.Comparisons were drawn between the two contrast agents in terms of the signal-to-noise ratio(SNR)of infarcted myocardium(SNRIM),SNR of the left ventricular blood pool(SNRLV),and contrast-of-noise ratio(CNR)between the infarcted myocardium and remote myocardium(CNRIM-RM)and CNR between the infarcted myocardium and left ventricular blood pool(CNRIM-LV).The difference in vol-ume of the total left ventricular infarcted myocardium at the three time intervals was compared within the same group.Re-sults At 5-8 mins,no significant difference was found between the two groups in SNRIM,SNRLV,CNRIM-RM and CNRIM-LV(P>0.05),the first two being having no significantly different within the same group(P>0.05).The volume of the total left ventricular infarcted myocardium cannot be accurately measured.At 9-12 mins and 13-16 mins,respectively,SNRIM was found to be significantly higher than SNRLV both in two groups.Of note was the evidence that the SNRIM,SNRLV,CNRIM-RM and CNRIM-LV were significantly higher in group B than in group A(P<0.05).The volume of the total left ven-tricular infarcted myocardium at these two time intervals within the same group were no significant difference(P>0.05).Conclusion Single-dose gadobutrol is superior to single-dose gadopentetate dimeglumine at the two time intervals of 9-12 mins and 13-16 mins in heart failure patients who are recommended to undergo cardiac late gadolinium enhancement MRI to evaluate the extent of infarcted myocardium.
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