Evaluating the Curative Effect of Pemetrexed Disodium +Platinum for Advanced Lung Adenocarcinoma Chemotherapy Based on Chest Enhanced CT Radiomics:A Feasibility Study
Objective To explore the feasibility of predicting the efficacy of pemetrexed disodium plus platinum chemo-therapy based on chest enhanced CT images of patients with advanced lung adenocarcinoma before treatment.Methods The clinical and enhanced CT data of 131 patients with lung adenocarcinoma diagnosed by puncture pathology in our hospi-tal from January 2018 to November 2022 were collected retrospectively.The patients were divided into training group(n = 92)and test group(n = 39)according to 7∶ 3 proportional sampling method.According to RECIST criteria,the patients were divided into remission group(n = 68)and non-remission group(n = 63).The combinatorial features of CT images before treatment were extracted and screened,and based on the final eigenvalues,support vector machine(support vector machine,SVM),logical regression(logistic regression,LR)and Gaussian process(Gaussian process,GP)classifiers were used to construct the imaging model.The predictive ability,diagnostic efficiency and clinical application value of the three models were analyzed and compared by subject working characteristic curve and decision curve.Results The AUC of the training set of the three models was 0.821,0.812 and 0.827,and the AUC of the test set was 0.664,0.714 and 0.709 re-spectively,the difference was not statistically significant,and the decision curve analysis showed that the net income of GP and SVM was higher than that of LR;while there was no significant difference between the training set and the test set of GP and SVM.Conclusion The imaging model based on chest enhanced CT is feasible for pemetrexed disodium plus platinum in the treatment of advanced lung adenocarcinoma,and the clinical net benefit of GP and SVM is better than that of LR within a certain threshold.
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