Objective This study aimed to explore the correlation between ring wall enhancement types of Glioblastoma and inflammation by quantitative and semi-quantitative analysis of dynamic contrast enhancement.Methods Twenty-three GBM patients and seventeen Inflammatory lesion patients(eleven brain abscess and six tuberculomas),who confirmed by pathology,were retrospectively analyzed between September 2015 and September 2020.The tumor wall of GBM was com-posed of two types:thick and irregular ground glass enhancement and thin and smooth thin wall enhancement.For inclusion in this study,patients need to have undergone a chest 3.0 T MRI examination within 2 weeks before surgery.MRI examina-tion include T1-weighted MRI,T2-weighted MRI,T1 enhancement MRI and DCE.The region of interest(ROI)of the lar-gest layer of tumor and inflammatory lesions was manually delineated on DCE images using GE Omni-Kinetics Version soft-ware.The DCE parameters of thick wall ground-glass enhancement pattern(group 1),thin wall enhancement pattern(group 2)and inflammatory lesion ring enhancement pattern(group 3)were compared.Including the difference of volume transfer constant(Ktrans),volume of the extracellular space(Ve),area under curve(AUC),back flux Constant(Kep),plasma vol-ume fraction(Vp),time to peak(TTP)and maximum rise slope(MAXslope).Ktrans,AUC and Vp were compared between the three groups with use of the variance analysis and least significant difference(LSD).Ve,Kep,TTP and MAXslope were compared between the three groups with use of the rank sum test and Kruskal-Wallis test.Results There were significant differences in Ktrans,AUC and MAXslope among the three groups(P＜0.05).The Ktrans,AUC,and MAXslope of the thick-walled ground-glass enhancement area of GBM were higher than those of the thin-walled enhancement area and the ring-wall enhancement of inflammatory lesions.There were no significant differences in Ktrans,AUC and MAXslope of the latter two areas(P＞0.05).Conclusion The thin-walled enhancement area of GBM has similar hemodynamic and permeability characteristics to the circumferential wall enhancement area of inflammatory lesions,and it is speculated that the inflammato-ry process may be involved in the thin-walled enhancement area of GBM.
GlioblastomaDynamic contrast enhancementVolume transfer constant
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