Objective To explore the arterial spin labeling(ASL)based on magnetic resonance imaging technology for arterial blood perfusion change pattern and its diagnostic value in patients with migraine without aura.Methods This study prospectively collected 35 migraine patients without aura(MWoA group)and 42 healthy control groups(HC group)who were matched for age,sex and education from January 2020 to December 2022 at Taizhou People's Hospital.The whole brain ASL scan was performed in both groups.Two-sample t test was used to statistically analyze and evaluate the CBF val-ues of each brain region in the two groups.After that,spearman correlation analysis was used to explore the correlation be-tween CBF value of brain area with blood perfusion difference and the course of disease,headache attack frequency,migraine Disability Assessment Scale(MIDAS),Digital Pain Assessment Scale(NRS),headache Impact Measurement-6 score(HIT-6).Receiver operating characteristic(ROC)curve was used to determine whether CBF values in different brain re-gions could be used to evaluate the diagnostic value of migraine without aura.Results Compared with healthy controls(HC),patients with migraine without aura had lower CBF values in the bilateral middle occipital gyrus(P＜0.05,FEW adjusted).Correlation analysis showed that there was no significant correlation between CBF value of bilateral middle occip-ital gyrus and duration of disease,headache frequency and migraine related pain scale.ROC analysis showed that the CBF values of the bilateral middle occipital gyrus had good diagnostic value for patients with migraine without aura.When the cut-off values were 1.035 and 1.055,the AUC values were 0.8027 and 0.7980,respectively,both P＜0.001.Conclusion There is abnormal blood perfusion in the brain of patients with migraine without aura.Moreover,the CBF values of these brain regions have ideal diagnostic value for distinguishing migraine patients without aura from normal people.
Migraine without auraArterial spin labelingMagnetic resonance imagingCerebral perfusion
NETL
NSTL
万方数据
