Objective To evaluate the relationship between motor deficits and crossed cerebellar diaschisis(CCD)after cerebral infarction using 320-slice CT whole-brain perfusion imaging.Methods A total of 115 patients with acute and suba-cute unilateral supratentorial cerebral infarction confirmed by MRI were enrolled as the experimental group,and 10 normal vol-unteers were enrolled as the control group.All patients underwent CT whole brain perfusion scan during the stable phase of symptoms,and the motor impairment grade was evaluated in the experimental group.Results CCD occurred in 45 cases in the experimental group,and there was no significant difference in the perfusion value of bilateral cerebellar hemispheres in the control group(P>0.05).In the acute cerebral infarction group,the incidence of CCD in patients with muscle strength score above grade 3 was 21.9%.The incidence of CCD in patients with grade 1-3 was 55%.The incidence of CCD in grade 0 pa-tients was 66.7%.In subacute cerebral infarction group,the incidence of CCD was 35.1%in patients with muscle strength score above grade 3.The incidence of CCD was 50%in the cases between 1 and 3.The incidence of CCD in grade 0 patients was 100%.The muscle strength score of CCD-positive group was lower than that of CCD-negative group in subacute stag(P<0.05).△TTP and △MTT in the cerebellum were negatively correlated with the muscle strength score in the CCD-positive group at acute stage,and the reduction rates of △TTP,△MTT and CBF in the cerebellum in the CCD-positive group at suba-cute stage were negatively correlated with the muscle strength score.Conclusion 320-slice CT whole-brain perfusion scan can effectively evaluate CCD after cerebral infarction.CCD is more likely to occur in patients with severe motor impairment after cerebral infarction.Cerebellar asymmetry index is related to the degree of motor impairment.