PD-1抗体联合安罗替尼及125I粒子链置入治疗肝门部胆管癌的疗效初探(附3例分析)
Preliminary Study on the Efficacy of PD-1 Antibody Combined with Antirotinib and 125I seed Chain Implantation in the Treatment of Perihilar Cholangiocarcinoma(Analysis of 3 Cases)
吴白露 1李臻 1韩新巍 1李鑫 1谢炳灿 1张玉元 1余鹏 1李一帆 1吕培杰 2葛鹏磊 3程兵4
作者信息
- 1. 450052 郑州大学第一附属医院放射介入科
- 2. 450052 郑州大学第一附属医院放射科
- 3. 450052 郑州大学第一附属医院肝胆外科
- 4. 450052 郑州大学第一附属医院核医学科
- 折叠
摘要
目的 探讨PD-1抗体联合安罗替尼及125I粒子链置入治疗肝门部胆管癌的初步疗效及安全性.方法 回顾性分析3例肝门部胆管癌患者的临床资料,均经病理结合实验室检查及影像学检查确诊,在DSA引导下行经皮肝穿胆道造影术,置入胆道支架及125I粒子引流管,后续配合替雷利珠单抗及安罗替尼规律治疗.结果 3例患者手术均成功,粒子引流管有效覆盖胆管病变区域,配合替雷利珠单抗及安罗替尼等药物治疗后病情均得到有效控制.结论 替雷利珠单抗联合安罗替尼及125I粒子链置入治疗肝门部胆管癌安全有效.
Abstract
Objective To investigate the initial efficacy and safety of PD-1 antibody combined with antirotinib and 125I seed chain implantation in the treatment of perihilar cholangiocarcinoma.Methods Clinical data of 3 patients with peri-hilar cholangiocarcinoma admitted to our department from April to January 2021 were retrospectively analyzed.All of them were confirmed by pathology combined with laboratory examination and imaging examination.Under the guidance of DSA,percutaneous transhepatic cholangiography was performed,biliary stent and 125I particle drainage tube were inserted,and then regular treatment was performed with tirelizumab and anrotinib.Results All the three patients were successfully op-erated.Particle drainage tube effectively covered the diseased area of bile duct,and the disease conditions were effectively controlled after treatment with tiralizumab and anrotinib.Conclusion Tirelizumab combined with allotinib and 125I seed chain implantation is safe and effective in the treatment of perihilar cholangiocarcinoma.
关键词
肝门部胆管癌/125I粒子链/替雷利珠单抗/安罗替尼/联合治疗Key words
Perihilar cholangiocarcinoma/125I particle chain/Tirelizumab/Anrotinib/Combination therapy引用本文复制引用
基金项目
国家自然科学基金(U1904143)
省部共建重点项目(SBGJ202102099)
河南省重大公益专项(201300310400)
出版年
2024
NETL
NSTL
万方数据