增强T2 FLAIR-T1 WI强化不匹配特征预测弥漫性胶质瘤IDH突变状态的价值
The Predictive Value of Enhanced T2 FLAIR-T1WI Mismatch Feature in Predicting IDH Mutation Status in Diffuse Glioma
梁泓中 1郭睿 2肖运平3
作者信息
- 1. 530200 广西中医药大学;545006 广西医科大学附属柳州市人民医院放射科
- 2. 545006 广西医科大学附属柳州市人民医院放射科;545006 柳州市分子影像重点实验室
- 3. 545006 广西医科大学附属柳州市人民医院放射科;545006 柳州市分子影像重点实验室;545006 广西临床疾病生物技术研究重点实验室
- 折叠
摘要
目的 探讨增强T2 FLAIR-T1WI强化不匹配特征预测弥漫性胶质瘤IDH突变状态的诊断价值.方法 分析经病理确诊的65例弥漫性胶质瘤患者术前MRI增强T,WI、增强T2 FLAIR强化特征,比较IDH突变组(27例)与野生组(38例)弥漫性胶质瘤增强T2 FLAIR-T1WI强化不匹配比例的差异.结果 IDH突变组与野生组的增强T1WI强化程度、比例有统计学差异(P＜0.05),IDH突变组与野生组在增强T2 FLAIR的强化程度、比例有统计学差异(P＜0.05),IDH突变组与野生组在增强T2 FLAIR-T1WI强化不匹配比例上差异具有统计学意义(P＜0.05).对IDH突变状态的预测,强化不匹配比例的敏感度、特异度、AUC值分别为81.6％、62.0％、0.767.结论 增强T2 FLAIR-T1WI强化不匹配特征有助于术前预测弥漫性胶质瘤的IDH突变状态.
Abstract
Objective To investigate the diagnostic value of enhanced T2 fluid-attenuated inversion-recovery(FLAIR)-T1 WI mismatch feature in predicting isocitrate dehydrogenase genes(IDH)mutation status in diffuse glioma.Methods 65 cases of diffuse glioma confirmed by histopathology were analyzed for enhancement features on preoperative MRI contrast-enhanced(CE)-T1 WI and CE-T2 FLAIR.The difference in the proportion of enhanced T2 FLAIR-T1WI mismatch between IDH mutation(27 cases)and wild-type(38 cases)diffuse gliomas was compared.Results There were statistically signifi-cant differences(P＜0.05)in the enhancement quality and proportion enhancing on CE-T1WI and CE-T2 FLAIR between the IDH mutation and wild-type groups.The difference in the proportion of enhanced T2 FLAIR-T1 WI mismatch was statisti-cally significant(P＜0.05)between the two groups.For predicting IDH mutation status,the sensitivity,specificity,and AUC value of the proportion of enhanced mismatch were 81.6％,62.0％,and 0.767,respectively.Conclusion En-hanced T2 FLAIR-T1WI mismatch feature can help predict IDH mutation status in diffuse glioma preoperatively.
关键词
弥漫性胶质瘤/磁共振成像/液体衰减反转恢复/增强/异柠檬酸脱氢酶Key words
Diffuse glioma/Magnetic resonance imaging/Fluid-attenuated inversion-recovery/Contrast-enhanced/Isocitrate dehydrogenase引用本文复制引用
基金项目
柳州市科技计划(2022CAC0208)
广西壮族自治区卫生健康委自筹经费课题(Z-B20221364)
广西壮族自治区卫生健康委自筹经费课题(Z20190350)
出版年
2024
NETL
NSTL
万方数据