Objective To investigate the changes of gray matter volume and functional connectivity of some brain re-gions in patients with Diabetic retinopathy(DR).Methods A total of 20 DR individuals(DR Group,n=20)and 23 healthy controls(HCs,n=23)were enrolled in this study.We performed psychological cognitive testing,structural and rest-ing functional magnetic resonance imaging(fMRI)scans respectively.Voxel-based morphometry(VBM)was used to ana-lyze gray matter volume,and the regions with volumetric variation were selected as regions of interest(ROI)for whole-brain functional connectivity(FC)analysis.The gray matter volume and functional connection were compared by two-sample t test.spearman correlation analysis was used to investigate the relationship between gray matter volume(GMV)and func-tional connection values in different brain areas and psychological cognitive test results.Results Compared with the HC group,the gray matter volume of the right medial frontal gyrus(MNI:x,y,z=40.5,10.5,42)and the right fusiform gyrus(MNI:x,y,z=30,-49.5,-12)decreased in DR Patients.Gray matter volume increased in the right orbital medial fron-tal gyrus(MNI:x,y,z=9,67.5,-7.5),right thalamus(MNI:x,y,z=10.5,-9,3),left medial occipital gyrus(MNI:x,y,z=-40.5,-85.5,24),right precental gyrus(MNI:x,y,z=54,1.5,46.5).With the right precental gyrus as the seed point,functional connections with the left superior temporal gyrus(MNI:x,y,z=-60,-30,18)and the left median cin-gulate and paracingulate gyri(MNI:x,y,z=-6,0,33)were weakened.There was no significant correlation between GMV and FC values and psychological cognitive outcomes in DR Patients.Conclusion In DR patients,the volume of gray mat-ter in some areas of the brain is changed,and functional connections with multiple brain regions are impaired,which may be one of the neuropathological bases of cognitive,emotional and behavioral disorders.
Diabetes mellitus type 2Diabetic retinopathyFunctional magnetic resonance imagingGray matter vol-umeVoxel-based morphometryFunctional connection
NETL
NSTL
万方数据
