Objective Quantitative susceptibility mapping and neurite orientation dispersion and density imaging were used to explore the evolution of iron deposition and microstructure in the brain of PD patients with disease progression and the relationship between them.Methods 41 PD patients were divided into early PD group(PD-1)and middle-late PD group(PD-2)according to Hoenh-Yahr stages.In addition,23 healthy volunteers were recruited in this study.The differ-ences between the groups were tested by single factor analysis of variance,and the correlation between the parameters of QSM and NODDI was analyzed by Spearman correlation.Results Compared to HC group,several nuclear groups showed different degrees of decrease in Vic,Viso and ODI values and abnormal increase in iron deposition.In the early PD group,there was a correlation between QSM values and ODI values of the substantia nigra and red nucleus,as well as between QSM values and the ODI values or Viso values of pallidus(r=-0.532,P=0.016;r=0.514,P=0.020;r=-0.516,P=0.020,r=-0.479,P=0.033)However,in the middle-late PD group,there was a positive correlation between QSM values and Vic values of the shell nucleus,as well as between QSM values and Vic or ODI values of pallidum.(r=0.610,P=0.003,r=0.575,P=0.006,r=0.508,P=0.019).Conclusion Excessive iron deposition and alterations of brain mi-crostructure exist in PD patients,and there is a correlation between excessive iron deposition and microstructural alterations.
Parkinson's diseaseQuantitative susceptibility mappingNeurite orientation dispersion and density ima-ging
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