Objective To investigate the predictive value of 18F-deoxyglueose(FDG)PET/CT maximum standardized uptake value(SUVmax),tumor metabolic volume(MTV),and total focal glycolysis(TLG)on the solid/micro papillary component of lung adenocarcinoma.Methods The clinicopathological data and preoperative 18F-FDG PET/CT metabolic parameters of 73 patients with pathologically confirmed invasive lung adenocarcinoma with lesions ≤3 cm in diameter were retrospectively collected and divided into M/P+group with solid/micropapillary component and M/P-group without sol-id/micropapillary component according to pathological histological subtypes,and the differences of each parameter between M/P+and M/P-groups in univariate analysis were compared using Mann-Whitney U test or x2 test,and independent in-fluences on the presence of solid/micropapillary component in lung adenocarcinoma were analyzed using multifactorial logis-tic regression,and their predictive efficacy was analyzed using subject operating characteristic(ROC)curves.Results Univariate analysis revealed that SUVmax(P=0.002),lymph node metastasis(P=0.029),and tumor stage(P=0.011)were associated with the M/P+group,and MTV(P=0.462),TLG(P=0.188),gender(P=0.239),smoking history(P=0.158),age(P=0.193),CEA levels(P=0.205)were not statistically different between the two groups.Multifacto-rial analysis showed that SUVmax was an independent influence on the presence of solid/micropapillary component in lung adenocarcinoma(OR:1.209,95％CI:1.035-1.411;P=0.016).ROC curve analysis showed that the area under the curve(AUC)of SUVmax predicting the presence of solid/micropapillary component in lung adenocarcinoma lesions was 0.710(95％CI:0.589-0.830;P=0.002),and the best cut-off value for SUVmax prediction was 8.10.Conclusion SUVmax had better predictive efficacy for primary lung adenocarcinoma lesions containing solid/micropapillary components,and SUVmax was an independent influential factor in predicting the presence of solid/micropapillary components in lung ade-nocarcinoma.
NETL
NSTL
万方数据
