Objective To investigate the correlation between diffusion kurtosis imaging(DKI)histogram parameters and Ki-67 and TTF-1 expression in lung cancer.Methods 61 lung cancer patients confirmed by pathology were prospec-tively collected.All patients underwent MRI examination within one week before surgery,andDWI and DKI images were an-alyzed.Histogram parameters of apparent diffusion coefficient(ADC),mean kurtosis(MK)and mean diffusivity(MD)were obtained by post-processing,and the expression results of immunohistochemical markers Ki-67 and TTF-1 were recor-ded.The correlation between each histogram parameter and Ki-67 and TTF-1 expression was assessed,and the diagnostic ef-ficacy of each parameter in predicting Ki-67 and TTF-1 expression was further determined by receiver operating characteris-tic curve(ROC).Results MD value 10th percentile,ADC value 10th percentile,kurtosis were negatively correlated with TTF-1 expression(r=-0.334--0.372,P＜0.05).MD value IQR,ADC value 90th percentile,IQR were positively cor-related with TTF-1 expression level(r=0.250-0.430,P＜0.05),and the MD value IQR had the highest diagnostic effi-ciency,and the area under the curve(AUC)was 0.774.The sensitivity was 45.45％and the specificity was 100％.MD value 90th percentile,max,IQR and skewness were negatively correlated with Ki-67 expression(r=-0.260--0.325,P＜0.05),with the highest diagnostic efficacy being max with an ROC curve showing an area under the curve(AUC)of 0.700,sensitivity of 51.22％and specificity of 95％.Conclusion Some parameters of DKI histogram are correlated with the expression of Ki-67 and TTF-1 in lung cancer,which can be used to predict their expression.
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