Objective To investigate the effect of visceral adipose tissue on the accuracy of preoperative T-staging of gastric cancer.Methods 366 patients with gastric cancer who were treated and treated were retrospectively collected.Ac-cording to the difference between clinical T stage(cT)and postoperative pathological T stage(pT),patients with gastric cancer were divided into accurate-and mis-staging groups.Compare individual characteristics of patients and adipose tissue parameters at L2/L3 level and maximum tumor level,including gender,age,BMI,thickest tumor diameter,visceral adipose tissue(VAT)area and density,subcutaneous adipose tissue(SAT)area and density.Multivariate logistic regression was used to determine the independent factors affecting the accuracy of cT staging.Results Among 366 patients,164(45%)were wrong in cT staging.There were statistically significant differences in VAT area(SVAT1),VAT average density(DVAT1),SAT area(SSAT1)and SAT average density(DSAT1)at L2/L3 level between the accurate-staging group and the mis-staging group.The difference of VAT area(SVAT2),average VAT CT value(DVAT2)and SAT area(SSAT2)at the largest tumor level was also statistically significant(P<0.05).Multivariate analysis results showed that L2/L3 level SVAT1(≥35.80 cm2)and the largest tumor level SVAT2(≥13.82 cm2)were independent risk factors for accurate evaluation of preoperative T-staging of gastric cancer.The OR(95%CI)were 2.771(1.243-6.181)and 2.938(1.635-5.277),re-spectively.Conclusion Both L2/L3 level and VAT area of the largest tumor level are important factors for accurate preop-erative T-staging assessment of gastric cancer.