Objective To observe the functional connections of the brain regions with structural abnormalities in adoles-cents with insomnia using the RSFC method based on functional magnetic resonance imaging(fMRI).Methods fMRI images,sleep status Self-rating Scale(SRSS),Pittsburgh Sleep Quality Index(PSQI),insomnia Severity Index(ISI),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were collected from 28 insomnia adolescents and healthy controls,Montrealer Cognitive Assess-ment Scale(MoCA),voxel-based morphological analysis method(VBM)to explore brain structural changes,RSFC to ana-lyze functional connectivity(FC)values between brain regions with altered brain structures and other voxels,and to analyze the correlation between abnormal FC brain regions and clinical scale scores.Results Compared with the healthy control group,FC was enhanced in the right anterior cuneiform lobe,left superior parietal lobe,left anterior central gyrus,and right middle temporal gyrus in the adolescent insomnia group(P＜0.05,FDR correction).FC was weakened in the right puta-men and some undefined brain areas(P＜0.05,FDR correction);The VBM volume of the right anterior cuneate lobe was negatively correlated with the PSQI fraction(P=0.041).There was a positive correlation between FC and SAS scores in the right anterior cuneus and the right middle temporal gyrus(P=0.024).The score of the MoCA scale was significantly decreased in the adolescent insomnia group,and the scores of SRSS,PSQI,HAMA,and HAMD were significantly increased compared with the healthy control group,and the difference was statistically significant.Conclusion The abnormalities of VBM and FC in the frontal lobe,parietal lobe,and precuneus of insomnia in adolescents may be related to anxiety,depres-sion and other adverse emotions,cognitive function reduction,and other symptoms.
NETL
NSTL
万方数据
