Objective To investigate the relationship between plaque with napkin-ring sign(NRS)and acute ischemic stroke(AIS)based on cervicocerebral CTA(computed tomography angiography).Methods A total of 225 patients who underwent cervicocerebral CTA and found NRS plaques between January 2019 and May 2023 were included,which were divided into two groups(113 patients with AIS and 112 individuals without AIS).The frequency and distribution of plaques with NRS in two groups were compared.Logistic regression analysis was used to screen the risk factor of ischemic stroke.Results The mean number and area of NRS plaques in the AIS group were greater than those in the control group[1.89±1.13 vs.1.39±0.61,P=0.001;(23.96±23.02)mm2 vs.(11.12±8.62)mm2,P<0.001],as well as in the ipsilateral culprit vessel and contralateral side to AIS[1.50±0.86 vs.0.39±0.65,P<0.001;(11.64±8.53)mm2 vs.(4.64±9.56)mm2,P<0.001].There were no differences in the degree and distribution of luminal stenosis between two groups.NRS plaques were most commonly found in the common carotid arteries in both groups.Logistic regression analysis showed that the number of NRS plaques was an independent risk factor for AIS.Conclusion The assessment of NRS plaques utilizing cervicocerebral CTA could be an essential target for the prevention and management of ischemic events.