Objective The relationship between changes in structural brain networks and cognitive function in young smokers was explored by diffusion tensor imaging(DTI).Methods DTI data were collected from 29 young smokers and 30 sex-and age-matched healthy controls,respectively,and a structural network was built using a deterministic fiber tracking assignment method.The correlations between global attributes,local attributes,Rich club and clinical information of Young smokers were analyed.Results Both groups had small world attributes.The smoking group showed a decrease in charac-teristic path length(Lp=5.9922±0.3322)and clustering coefficient(Cp=0.2608±0.0214),while the global efficien-cy(Eglob=0.1674±0.0093)and local efficiency(Eloc=0.2813±0.0137)were enhanced.The node efficiency of right superior frontal gyrus,right gyrus rectus,right anterior cingulate and paracingulate gyrus,right calcarine fissure and sur-rounding cortex,and left postcentral gyrus in the smoking group increased(P＜0.01,FDR correction).Meanwhile,the con-nection strength of the rich club in the smoking group 1 was significantly enhanced(P＜0.001).The local efficiency of the smoking group was positively correlated with the cigarette per day(CPD).Conclusion Abnormal changes in the structur-al network of young smokers may provide imaging evidence for cognitive functionimpairment and assessment.
Young smokersDiffusion tensor imagingBrain structurenetworkRich club
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