Objective This study aims to investigate the functional and structural abnormalities in Parkinson's disease patients with fatigue(PDF).Methods A total of 32 PDF patients,32 Parkinson's disease patients without fatigue(nP-DF),and 36 normal controls(NCs)were included.The amplitude of low-frequency fluctuation(ALFF)method was uti-lized to analyze neuronal activity,while the voxel-based morphometry method was employed to observe gray matter volume(GMV)in the three groups.Finally,the correlation between imaging indicators and FSS scores was examined.Results Compared to nPDF and NCs group,significantly decreased ALFF values in the PDF group were observed in the bilateral pre-cuneus,the right thalamus/caudate nucleus(THA/CAU),the left thalamus/hippocampus(THA/HIP)and the right ro-landic operculum/putamen/insula;Gray matter atrophy was found in the right hippocampus/amygdala/putamen(HIP/AMYG/PUT)and the left temporal pole(superior temporal gyrus)/amygdala/putamen(TPOsup/AMYG/PUT).In addi-tion,FSS scores in the PDF group were negatively correlated with the ALFF values in the left THA/HIP and right THA/CAU,as well as the GMV values in the right HIP/AMYG/PUT and left TPOsup/AMYG/PUT.Conclusion The abnormal function and structure in the limbic lobe,thalamus,basal ganglia and parietotemporal lobe may be implicated in the occur-rence and progression of PDF.
Parkinson's diseaseFatigueFunctional magnetic resonance imagingAmplitude of low-frequency fluc-tuationVoxel-based morphometry
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