Objective The purpose of this study is to explore the changes of brain function and its correlation with clin-ical features in first-episode untreated adolescents with depressive disorder by resting-state functional magnetic resonance imaging(fMRI).Methods A total of 31 patients with depression and 30 matched healthy controls underwent resting-state fMRI scanning.The differences in amplitude of low frequency fluctuation(ALFF)between the depression group and the control group were compared.Subsequently,these differential brain regions were used as seed points for whole-brain func-tional connectivity(FC)analysis to compare intergroup differences.The ALFF and FC values in the differential brain re-gions of the depression group were extracted and correlated with clinical features.Results Compared with control group,ALFF value of left thalamus was decreased in depression group,while that of the right calcarine fissure and surrouding cor-tex,left dorsolateral superior frontal gyrus,right superior marginal gyrus,left superior occipital gyrus was increased(cluster level P＜0.05,FWE corrected).In addition,compared with control group,right calcarine fissure-seed and left thalamus seed FCs of depression were significantly decreased.ALFF value of the left thalamus was negatively correlated with the HAMD-17 score(r=-0.439,P=0.013).Conclusion In the early stage of the disease,adolescents with depressive disorder show abnormal spontaneous neural activity and dysfunction of functional connectivity in the thalamus,and these changes are related to the severity of depression,which may be the neuropathological pathogenesis of adolescent depression.
Depressive disorderFunctional magnetic resonance imagingFunctional connectivityAmplitude of low frequency fluctuation
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