Objective To explore the value of FLAIR vascular hyperintensity(FVH)-diffusion weighted image(DWI)mismatch and prominent vessel sign(PVS)-DWI mismatch in evaluating prognosis of acute ischemic stroke(AIS)under different collateral circulation status.Methods Eighty-seven cases of consecutive AIS patients without reperfusion treat-ment were enrolled.All patients were divided into poor and good neurologic function group according to modified Rankin score(mRS).Chi square,t-test and Mann-Whitney U test was performed to test the differences between the two groups.All patients were divided into subgroup of poor and good collateral circulation according to regional Leptomeningeal Collateral(rLMC).Then the multivariate logistic regression model was set up to determined independent predictors for AIS prognosis in subgroup.Results For all patients,rLMC,NIHSS(on admission and two weeks later)were independent prognostic predictors of AIS(all P＜0.05).While,FVH-DWI mismatch and PVS-DWI mismatch were not independent predictors(P=0.356;P=0.156).For poor collateral circulation subgroup,rLMC,FVH-DWI mismatch,and NIHSS(two weeks later)were independent prognostic predictors of AIS(Regression Model 1);rLMC and PVS-DWI mismatch were also independent prognostic predictors(Regression Model 2).For good collateral circulation subgroup,rLMC and NIHSS(two weeks later)were independent prognostic predictors(Regression Model 3).Conclusion When FVH-DWI mismatch and PVS-DWI mismatch are employed for prognosis assessment in AIS patients,the collateral circulation status should be evaluated at first.In those patients with poor collateral circulation,the FVH-DWI mismatch and PVS-DWI mismatch can rough estimate the existence of ischemic penumbra and indicate good prognosis of AIS.
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