乳腺MRI特征与乳腺癌P63表达的关系研究
Study on the Relationship between Breast MRI Characteristics and P63 Expression in Breast Cancer
姚雷 1崔碧 1吴振虎 1王晋君1
作者信息
摘要
目的 深入探讨乳腺癌中P63阳性与阴性表达患者的MRI特征差异,并分析其临床意义.方法 回顾性分析2020年2月至2022年10月本院收治的125例乳腺癌患者,其中包括P63阳性和阴性两组,评估其MRI形态学特征并通过交叉列联表进行统计分析.结果 P63阳性组与阴性组在MRI形态、边缘、内部强化特征及TIC类型上表现出显著差异.P63阴性组多表现为不规则形态和不均匀内部强化,而P63阳性组则以环形内部强化为主.两组的时间信号强度(TIC)曲线类型亦有明显不同.结论 乳腺癌中P63表达状态与MRI特征有显著相关性,这一发现对于术前预测、治疗方案的制定以及预后评估具有重要指导意义.
Abstract
Objective To thoroughly investigate the differences in MRI features between P63-positive and P63-negative breast cancer patients and analyze their clinical implications.Methods This retrospective study analyzed 125 breast cancer patients treated at our institution from February 2020 to October 2022,including groups with positive and negative P63 expression.We assessed their MRI morphological features and performed statistical analysis using cross-tabulation.Results Significant differences were observed between the P63-positive and P63-negative groups in terms of MRI morphol-ogy,margins,internal enhancement characteristics,and TIC curve types.Specifically,the P63-negative group predominantly exhibited irregular shapes and heterogeneous internal enhancement,while the P63-positive group primarily showed circular internal enhancement.The TIC curve types also significantly differed between the groups.Conclusion There is a signifi-cant correlation between P63 expression status and MRI features in breast cancer.These findings are crucial for preoperative prediction,designing treatment plans,and prognosis evaluation.
关键词
乳腺癌/磁共振成像/形态/边缘/内部强化特征/TIC类型/P63Key words
Breast cancer/Magnetic resonance imaging/Morphology/Margins/Internal strengthening characteris-tics/TIC type/P63引用本文复制引用
出版年
2024
NETL
NSTL
万方数据