摘要
目的 探讨动态对比增强磁共振成像(DCE-MRI)表现为非肿块强化(NME)的乳腺小叶癌与导管癌MRI表征的差异性,并对比分析病理相关指标.方法 回顾性分析92例MRI表现为NME的乳腺癌患者的MRI特征及临床病理资料.根据病理结果将患者分为小叶癌组(41例)和导管癌组(51例).分别采用x2检验或Fisher精确检验及Mann-Whitney U检验对比分析两组乳腺癌患者的MRI及临床病理资料,包括患者年龄、病变位置、病灶最大横径、乳腺腺体类型、是否多灶、瘤周水肿、NME分布及内部强化特征以及雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)状态、Ki-67指数、淋巴结转移等.结果 乳腺小叶癌与导管癌在病灶最大横径(P=0.010)、多灶间强化带(P=0.038)、NME 分布特征(P=0.042)、NME 内部强化特征(P＜0.001)、PR(P=0.047)、HER-2(P=0.004)、Ki-67 指数(P=0.011)、淋巴结转移情况(P=0.033)差异有统计学意义(P＜0.05);两组患者的病变位置(P=0.363)、腺体类型(P=0.293)、是否多灶(P=0.798)、瘤周水肿(P=0.518)和ER(P=0.162)差异无统计学意义(P＞0.05).结论 表现为NME的乳腺小叶癌与导管癌患者的MRI表征及病理相关指标存在一定差异,这些特征有助于二者的MRI诊断及鉴别诊断.
Abstract
Objective To explore the differences in MRI features between breast lobular carcinoma and ductal carcino-ma with non-mass enhancement(NME)on dynamic contrast-enhanced MRI(DCE-MRI),and to compare and analyze path-ological related indexes.Methods Imaging and pathological data of 92 breast cancer patients presenting with NME on MRI were retrospectively analyzed.They were divided into two groups according to the pathological results,including 41 ca-ses of lobular carcinoma and 51 cases of ductal carcinoma.Chi-Squared or Fisher exact test and Mann-Whitney U test were used to compare and analyze the imaging and pathological data of the two groups of patients,including age,location and size of lesions,type of mammary gland,multifoci,peritumoral edema,distribution and internal enhancement features of NME,es-trogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2)status,lymph node metastasis,etc.Results lobular carcinoma and ductal carcinoma showed statistical differences in the maximum transverse diameter(P=0.010),enhancing strands(P=0.038),NME morphological distribution(P=0.042),NME enhancement features(P＜0.001),PR(P=0.047),HER-2(P=0.004),Ki-67(P=0.011)and lymph node metastasis(P=0.033).There were no significant differences in lesion location(P=0.363),gland type(P=0.293),multifoci(P=0.798),peritumoral edema(P=0.518)and ER(P=0.162)between the two groups(P＞0.05).Conclusion There are certain differences in MRI features and pathological related indicators between breast lobular carcinoma and ductal car-cinoma with NME.MRI can provide assistance for the pre-treatment diagnosis of lobular carcinoma and ductal carcinoma with NME.
基金项目
山东省自然科学基金项目(ZR202103060229)
NETL
NSTL
万方数据