Objective To explore the value of quantitative parameters of intravoxel incoherent motion-weighted imaging(IVIM-DWI)combined with serum tumor markers in the differential diagnosis of small cell lung cancer(SCLC)and non-small cell lung cancer,NSCLC).Methods Eighty-nine patients with lung cancer confirmed by pathology from January 2021 to September 2023 were retrospectively analyzed andwere divided into 32 patientswith SCLC group and 57 patients with NSCLC group(20 with squamous cell carcinoma,37 with adenocarcinoma)according to the pathological results.Neuron-spe-cific enolase(NSE),carcinoembryonic antigen(CEA),cytokeratin 19 fragment antigen21-1(CYFRA21-1),diffusion coef-ficient(D),pseudo-diffusion coefficient(D*),perfusion fraction(f)and apparent diffusion coefficient(ADC)were de-tected.The predictive models of single serum tumor marker,single IVIM-DWI parameter,multiple serum tumor markers,multiple IVIM-DWI parameters,serum tumor markers+IVIM-DWI were constructed.The receiver operating characteristic(ROC)curve to analyze the diagnostic efficiency of each model.Results The level of NSE in SCLC group was higher than that in NSCLC group,while the levels of CEA and CYFRA21-1 were lower than those in NSCLC group,with statistical significance(P＜0.05).The values of D and ADC in SCLC group were lower than those in NSCLC group,and the differ-ence was statistically significant(P＜0.05).There was no significant difference in f and D* values between groups(P＞0.05).The AUC of NSE,CEA,CYFRA21-1,ADC value and D value single models identifying SCLC and NSCLC were 0.668,0.658,0.634,0.722,0.747and there was no significant difference among the models(P＞0.05).TheAUC of the three combined models was higher than that of the single index prediction model,and the combined model of serum tumor markers+ADC+D has the highest diagnostic efficiency(AUC=0.860).Conclusion Serum tumor markers combined with IVIM-DWI parameters can improve the differential efficacy of SCLC and NSCLC.
NETL
NSTL
万方数据
