Objective To evaluate the value of blood oxygenation level-dependent(BOLD)magnetic resonance ima-ging for the assessment of early diabetic nephropathy(EDN)by Meta-analysis system.Methods PubMed,Cochrane li-brary,CNKI,Wanfang,Wipu and China Biomedical Literature Database were searched from 2013.1 to 2023.11 to collect the research literature on BOLD assessment of EDN.Pooled analyses were performed using Revman 5.4 and Stata 16.0 soft-ware.Results 8 papers with 476 EDN patients were finally included.Pooled renal cortical R2*values(CR2*values)were significantly higher in the EDN group than in the control group,Weighted Mean Difference(WMD)=0.35[95％CI(0.18,0.51),P＜0.001;I2=70.3％,P＜0.05];and renal medullary R2* values(MR2* values)were significantly higher than in the control group,WMD=2.02[95％CI(1.67,2.38),P＜0.001;I2=87.2％,P＜0.05].Within the EDN group,the negative urinary protein subgroup had no difference in CR2* values compared with the control group,WMD=0.15[95％CI(-0.08,0.38),P=0.64;I2=0.0％,P=0.19];its MR2* value was significantly higher than that of the control group,WMD=1.89[95％CI(1.441,2.345),P＜0.001;I2=85.4％,P＜0.05].The CR2* values of the negative urinary protein subgroup did not differ from those of the control group,WMD=-0.03[95％CI(-0.29,0.24),P=0.85;I2=74.3％,P＜0.05];the MR2* values were significantly higher than those of the control group,WMD=1.22[95％CI(0.69,1.74),P＜0.001;I2=35.8％,P=0.18].Conclusion BOLD is an accurate,noninvasive imaging technique,and quantitative monitoring of MR2* values has the potential to play a role in EDN diagnosis and decision-mak-ing.
Early diabetic nephropathyOxygenation level dependentNuclear magnetic resonanceMeta-analysis
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