血氧水平依赖磁共振成像对早期糖尿病肾病评估价值的Meta分析
Blood Oxygenation Leveldependent Imaging in Evaluation of Early Diabetic Nephropathy:Meta-Analysis
张欣悦 1陆方 2徐亦曾 1王琛1
作者信息
- 1. 201203 上海中医药大学附属曙光医院肾内科
- 2. 201203 上海中医药大学附属曙光医院放射科
- 折叠
摘要
目的 通过Meta分析系统评价血氧水平依赖(BOLD)磁共振成像对早期糖尿病肾病(EDN)的评估价值.方法 检索PubMed、Cochrane library、CNKI、万方、维普和中国生物医学文献数据库,搜集BOLD对EDN评估的研究文献,检索时间为2013年1月至2023年11月.采用Revman5.4、Statal6.0软件进行汇总分析.结果 最终纳入8篇文献,共476例EDN患者.汇总后EDN组肾皮质R2'值(CR2*值)显著高于对照组,加权均数差(WMD)=0.35[95％CI(0.18,0.51),P＜0.001;I2=70.3％,P＜0.05];肾髓质R2*值(MR2*值)显著高于对照组,WMD=2.02[95％CI(1.67,2.38),P＜0.001;I2=87.2％,P＜0.05].EDN 组内,阴性尿蛋白亚组 CR2*值与对照组比较差异无统计学意义,WMD=0.15[95％CI(-0.08,0.38),P=0.64;I2=0.0％,P=0.19];MR2*值显著高于对照组,WMD=1.89[95％CI(1.441,2.345),P＜0.001;I2=85.4％,P＜0.05].阴性尿蛋白亚组 CR2*值与对照组比较差异无统计学意义,WMD=-0.03[95％CI(-0.29,0.24),P=0.85;I2=74.3％,P＜0.05];MR2*值显著高于对照组,WMD=1.22[95％CI(0.69,1.74),P＜0.001;I2=35.8％,P=0.18].结论 BOLD 是一种准确、无创的成像技术,定量监测MR2*值有可能在EDN诊断及决策中发挥作用.
Abstract
Objective To evaluate the value of blood oxygenation level-dependent(BOLD)magnetic resonance ima-ging for the assessment of early diabetic nephropathy(EDN)by Meta-analysis system.Methods PubMed,Cochrane li-brary,CNKI,Wanfang,Wipu and China Biomedical Literature Database were searched from 2013.1 to 2023.11 to collect the research literature on BOLD assessment of EDN.Pooled analyses were performed using Revman 5.4 and Stata 16.0 soft-ware.Results 8 papers with 476 EDN patients were finally included.Pooled renal cortical R2*values(CR2*values)were significantly higher in the EDN group than in the control group,Weighted Mean Difference(WMD)=0.35[95％CI(0.18,0.51),P＜0.001;I2=70.3％,P＜0.05];and renal medullary R2* values(MR2* values)were significantly higher than in the control group,WMD=2.02[95％CI(1.67,2.38),P＜0.001;I2=87.2％,P＜0.05].Within the EDN group,the negative urinary protein subgroup had no difference in CR2* values compared with the control group,WMD=0.15[95％CI(-0.08,0.38),P=0.64;I2=0.0％,P=0.19];its MR2* value was significantly higher than that of the control group,WMD=1.89[95％CI(1.441,2.345),P＜0.001;I2=85.4％,P＜0.05].The CR2* values of the negative urinary protein subgroup did not differ from those of the control group,WMD=-0.03[95％CI(-0.29,0.24),P=0.85;I2=74.3％,P＜0.05];the MR2* values were significantly higher than those of the control group,WMD=1.22[95％CI(0.69,1.74),P＜0.001;I2=35.8％,P=0.18].Conclusion BOLD is an accurate,noninvasive imaging technique,and quantitative monitoring of MR2* values has the potential to play a role in EDN diagnosis and decision-mak-ing.
关键词
早期糖尿病肾病/血氧水平依赖/核磁共振/Meta分析Key words
Early diabetic nephropathy/Oxygenation level dependent/Nuclear magnetic resonance/Meta-analysis引用本文复制引用
基金项目
国家自然科学基金项目(81973770)
上海市浦东新区卫生系统重点学科群建设资助项目(PWZxq2017-07)
出版年
2024
NETL
NSTL
万方数据