Objective To investigate the multi-slice spiral computed tomography(MSCT)features of atypical liver ab-scess caused by Klebsiella pneumoniae(KP).Methods 41 patients with KP atypical liver abscess confirmed puncture or surgery were reviewed retrospectively.All patients were performed dual-phases enhanced CT scan,MSCT findings were an-alyzed.Results In 41 cases of KP atypical liver abscess,70 lesions were identified.Vascular penetration was noted in 7 lesions,characterized by vascular thickening,indistinct margins and irregular invasive changes.2 cases were initially misdi-agnosed as primary hepatic lymphoma(PHL).Additionally,34 lesions displayed imaging patterns such as the"honey-comb,""petal,"or"cluster"signs,27 lesions demonstrated"lesion shrinkage"sign.Transient abnormal enhancement in hepatic parenchyma were observed in 46 lesions.Conclusion Vascular penetration with inflammatory infiltration was an important sign in the diagnosis of atypical liver abscess of KP,correctly recognize this sign could reduce misdiagnosis.