Objective The aim of this study was to observe the differences in the distribution of quantitative parameters of amide proton transfer imaging(APT)in benign and malignant lesions in different anatomical subdivisions of the prostate,and to investigate its diagnostic value for prostate cancer alone and its diagnostic efficacy in combination with ADC and PS-AD.Methods The prostate images and data of 74 patients who underwent routine multiparametric MRI combined with APT and DWI at the First Affiliated Hospital of Anhui Medical University from June to December 2023 were retrospectively analyzed,and they were divided into the benign lesion(BL)group and the prostate cancer(PCa)group,and the prostate was classified into the transmigratory zone(TZ)area and the peripheral zone(PZ)according to the anatomical subdivi-sions.The APT pseudo-color maps of the BL and PCa groups with different anatomical zones were observed,and the statis-tical differences in the quantitative parameters of APT,ADC and PSA-related indexes between the two groups were analyzed using the independent samples t-test or the Wilcoxon rank-sum test,and the differential diagnostic efficacies of the indexes with statistically significant differences were evaluated by plotting the working characteristic(ROC)curves of the subjects individually and in combination,respectively.Results APTmax and APTmean in TZ zone and APTmax,APTmean and APTmin in PZ zone in the PCa group were significantly higher than those in BL group(P＜0.05).TZ zone showed the highest AUC for APTmax+ADC+PSAD(AUC=0.918),with the sensitivity and specificity of 78.9％and 97.6％,re-spectively;The PZ zone indicates the highest AUC for APTmean+ADC+PSAD(AUC=0.929)with a sensitivity and specificity of 78.9％and 100％,respectively.Conclusion The quantitative parameters of APT were significantly higher in PCa group than in BL group in different anatomical subdivisions of the prostate,and the differential diagnostic value with APTmax and APTmean was higher,and the quantitative parameters of APT and ADC combined with PSAD had the highest differential diagnostic efficacy.
Amide proton transferProstate cancerApparent diffusion coefficientProstate-specific antigen density
NETL
NSTL
万方数据
