Objective Exploring factors influencing the occurrence of visceral pleural invasion(VPI)in early stage 30 mm non-small cell lung cancer.Methods The clinical,imaging and pathological data of 449 patients diagnosed as ear-ly-stage non-small cell lung cancer by postoperative pathology in Anqing Municipal Hospital,Zhejiang Tongde Hospital and the First Affiliated Hospital of Bengbu Medical University during the period of January 2021-November 2023 were retrospec-tively analyzed,and the patients were divided into two groups according to whether they had developed VPI or not,and the influencing factors of the development of VPI in non-small cell lung cancer were analyzed by unifactorial and multifactorial regression.Results Among the 449 patients,121 were in the VPI-positive group and 328 were in the VPI-negative group.Univariate analysis showed that the diameter of the lesion and the length of contact between the solid part and the pleura in the VPI(+)group were significantly larger than those in the VPI(-)group,and the CT values were higher;the age of the patients,history of lung diseases and clinical diseases,type of nodules and percentage of solid component of the lesion,morphology,lobular sign,burr sign,air-containing lumen,bronchial sign,the relationship of the lesion to the pleura,the number of pleural tags and obstructive inflammation were all statistically significant in the VPI(+)groups and VPI(-)groups were statistically significant(P value＜0.05),and multifactorial regression analysis showed that nodule type,num-ber of pleural tags,length of contact between the solid part of the lesion and the pleura,and CT value were the CT character-istic indexes of pleural invasion in non-small cell lung cancer.The areas under the curve of these factors individually and jointly predicted pleural invasion were 0.796,0.770,0.832,0.754,and 0.966,respectively.The sensitivity,specificity,and accuracy of the combined model were 90.1％,92.1％,and 90.9％,respectively.Conclusion When pleural invasion oc-curred in non-small cell lung cancer lesions,the lesions mostly showed partially solid nodules with a high proportion of solid components and solid nodules with high CT values,and the probability of pleural invasion was high when the solid portion of the lesion had a long length of contact with the pleura and had multiple pleural tags.
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