Objective To evaluated the therapeutic effect of extracorporeal shock wave(ESW)combined with rehabili-tation exercise on knee osteoarthritis(KOA)by MRI,and explored the correlation between MR findings and clinical symp-toms.Methods The clinical and image data of 62 KOA patients were obtained from a prospective study of extracorporeal shock wave for knee osteoarthritis.MR examination and clinical scoring of knee were performed before treatment and after 3 months of treatment.The Whole-Organ Magnetic Resonance Imaging Score(WORMS)was used to evaluate the MR findings and the area of bursae suprapatellaris fluid was measured.Visual Analogue Scale(VSA)and the Western Ontario and Me-Master Universities Osteoarthritis Index(WOMAC)were used to evaluate the therapeutic effect.Pre-treatment and post-treatment MR findings and clinical scores were compared and the regression analysis of MR findings and clinical symptoms was analyzed.Results Bone marrow edema,area of joint effusion,VSA and WOMAC were significantly different in pre-treatment and post-treatment(P<0.05).The cartilage score and VAS were significantly correlated.Conclusion Bone marrow edema and joint effusion area of MRI can reflect the treatment effect.Cartilage scores in MRI correlate with pain.ESW therapy combined with rehabilitation exercise has a positive effect on knee osteoarthritis,which can significantly allevi-ate joint effusion,bone marrow edema and clinical symptoms in patients.