首页|健康体检人群骨密度定量CT骨密度与HDL-C的相关性研究

健康体检人群骨密度定量CT骨密度与HDL-C的相关性研究

Correlation between HDL-C and Quantitative CT Measurement of Bone Mineral Density in Healthy Physical Examination Populations

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  • 维普
  • 万方数据
目的 分析健康体检人群的高密度脂蛋白胆固醇(HDL-C)与骨密度(BMD)之间的关系,为骨质疏松防治提供指导.方法 搜集河南省人民医院健康管理学科2018年9月至2023年2月17448例体检人群作为研究对象.所有研究对象均进行体格检查、血脂检测和定量CT(QCT)测量其腰椎BMD.采用Pearson和Spearman相关分析评估各指标与BMD的相关性,采用多元线性回归分析进一步分析HDL-C与BMD的关系.结果 按BMD分组:骨质疏松组血清HDL-C平均值显著高于骨量减少组和骨量正常组(P＜0.05).回归分析调整其他变量后结果显示,HDL-C水平与腰椎BMD呈负相关(t=-4.364,P＜0.05),且女性人群中的负相关更为显著(t=-6.858,P＜0.05).按体质量指数(BMI)分组:HDL-C水平与腰椎BMD在超重和肥胖人群中为负相关(r=-0.039,P＜0.01;r=-0.126,P＜0.01);而在BMI＜24 kg/m2组无相关,差异无统计学意义(P＞0.05).结论 血清HDL-C水平的升高是骨质疏松发生的危险因素,在女性以及超重和肥胖人群更为突出,为骨质疏松的预防提供科学依据.
Objective To analyze the relationship between high-density lipoprotein cholesterol(HDL-C)and bone mineral density in healthy physical examination populations to provide guidance for the prevention and treatment of osteopo-rosis.Methods This study was a retrospective study that collected 17,448 physical examination people from September 2018 to February 2023 in the health management discipline of Henan Provincial People's Hospital.All participants under-went physical examination,lipid profile and quantitative CT(QCT)to measure their lumbar spine bone density.Pearson and Spearman correlation analysis was used to evaluate the correlation between each index and bone density,and multiple linear regression analysis was used to further analyze the relationship between HDL-C and bone density.Results According to bone mineral density,the mean value of serum HDL-C in the osteoporosis group was significantly higher than that in the os-teopenia and normal bone mass group(P＜0.05).After adjusting for other variables,the results of regression analysis showed that HDL-C levels were negatively correlated with lumbar spine bone mineral density(t=-4.364,P＜0.05),and the negative correlation was more significant in the female population(t=-6.858,P＜0.05).According to body mass in-dex(BMI),HDL-C level was negatively correlated with lumbar spine bone mineral density in overweight and obese people(r=-0.039,P＜0.01;r=-0.126,P＜0.01).There was no correlation in the BMI＜24 kg/m2 group,and the differ-ence was not statistically significant(P＞0.05).Conclusion Elevated serum HDL-C levels are risk factors for osteopo-rosis,and are more prominent in women and overweight and obese people,providing a scientific basis for the prevention of osteoporosis.

High density lipoprotein cholesterolBone mineral densityOsteoporosisQuantitative CTBlood lipids

林新贝、孙永兵、戚昕、周阳、杜亚玮、邹智、朱嘉栋、吕雪、张弓、李昊、李永丽

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450003 郑州大学人民医院/河南省人民医院医学影像科

450003 郑州大学人民医院/河南省人民医院健康管理学科,河南省慢病健康管理重点实验室

230000 合肥,中加健康工程研究院(合肥)有限公司

451460 郑州,阜外华中心血管病医院健康管理学科

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高密度脂蛋白胆固醇 骨密度 骨质疏松症 定量CT 血脂

国家自然科学基金项目国家重点研发计划项目中原科技创新领军人才计划项目河南省医学科技计划项目河南省医学科技计划项目

820718842022YFC2010001244200510016SBGJ202302011LHGJ20231320

2024

临床放射学杂志
黄石市医学科技情报所

临床放射学杂志

CSTPCD北大核心
影响因子：0.872
ISSN：1001-9324
年,卷(期)：2024.43(10)