Objective To explore the value of diffusion kurtosis imaging(DKI)in the prognostic evaluation of neonatal hypoxic ischemic encephalopathy(HIE).Methods A total of 66 newborns diagnosed with HIE through MRI examination in our hospital were selected as the study subjects.Routine cranial MRI and DKI scans were performed,and the DKI derived parameters of the region of interest(ROI)were measured.Spearman rank correlation analysis was performed between these parameters and neonatal behavioral neurological assessment(NBNA)scores at 14 days and Gesell scores at 6 and 12 months.The Mann Whitney U rank sum test is used to compare the differences in DKI derived parameters between the group with good prognosis and the group with poor prognosis,and to analyze the prognostic efficacy of DKI derived parameters u-sing receiver operating characteristic curve(ROC curve).Results Some DKI derived parameters had a certain correla-tion with NBNA,6-month Gesell score,and 12-month Gesell score.The MK values of the caudate nucleus,the pressure part of the corpus callosum,the Ka values of the caudate nucleus,the Kr values of the globus pallidus and putamen,and the FA values of the central white matter at the central level of the semiovale showed significant differences between the good prog-nosis group and the poor prognosis group.The values of the good prognosis group were higher than those of the poor progno-sis group,and the combined diagnostic efficacy of all parameters was the highest(area under the curve was 0.815),The Kr value of the corpus callosum pressure can distinguish the difference between the good prognosis group and the poor prognosis group(area under the curve is 0.738),while the MK value and Kr value of the corpus callosum pressure can distinguish the difference between the good prognosis group and the poor prognosis group(area under the curve is 0.810 and 0.838,re-spectively).Conclusion DKI derived parameters can serve as potential prognostic indicators for neonatal HIE in clinical practice,providing relevant basis for developing better treatment plans.1.
维普
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