Objective To explore the central mechanism ofTai Chi in the treatment of chronic fatigue syndrome(CFS)from the perspective of functional connectivity(FC)of left frontoparietal network(LFPN).Methods 20 CFS patients and 20 healthy subjects were recruited in this study.Both groups of subjects received simplified 24-form Tai Chi training for 4 weeks.Fatigue Scale-14(FS-14),Hamilton Depression Scale(HAMD)scores and functional-MRI scans were performed before and after treatment in self-comparison and inter-group comparison.The correlation between scale and FC before and after treatment was analyzed.Results 1)The FS-14、HAMD score of CFS patients were significantly higher than healthy subjects(P＜0.01),and then decreased(P＜0.01).2)The FC in the LFPN was significantly lower in CFS patients,and then was significantly enhanced in the dorsal prefrontal lobe and parietal lobule,especially in the left inferior frontal gyrus,left anterior cingulate gyrus and medial prefrontal lobe.The FC in the right medial temporal lobe and right dorsal prefrontal lobe was significantly enhanced in healthy subjects after treatment.3)The FC difference of LFPN before and after treatment in CFS patients was negatively correlated with the difference of FS-14(r=-0.791,P＜0.001),and had no correlation with the difference of HAMD(R=0.0273,P=0.9).Conclusion Tai Chi can improve the fatigue degree of CFS pa-tients by strengthening the FCof LFPN,particularly regulating the functional activities of left inferior frontal gyrus,left anteri-or cingulate gyrus and medial prefrontal cortex.These findings could advance our understanding of treatment of Tai Chi.
Tai ChiChronicFatigue Syndrome(CFS)Functional Magnetic Resonance Imaging(fMRI)Left fron-toparietal network(LFPN)Functional connectivity(FC)
维普
万方数据
