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心脏超声及MRI在扩张型心肌病预后评估中价值分析

Value of Cardiac Ultrasound and MRI in Prognosis Evaluation of Dilated Cardiomyopathy

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目的 分析心脏超声及MRI在扩张型心肌病预后评估中的价值.方法 选取2020年1月至2023年1月医院收治的110例扩张型心肌病患者,所有患者均进行心脏超声、MRI检查以及追踪随访并记录预后情况.采用Cox回归分析心脏超声及MRI相关参数与扩张型心肌病患者预后的关系,绘制受试者工作特征(ROC)曲线分析两者对于扩张型心肌病预后的评估价值.结果 110例患者中42例患者出现终点事件(预后不良组),其余68例未出现终点事件(预后良好组);预后不良组心脏超声右心室内径(RV)、左心室收缩末期内径(LVSd)、左心房内径(LA)、左心室舒张末期内径(LVDd)高于预后良好组(P<0.05);预后不良组MRI左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)高于预后良好组,每搏输出量(SV)、左心室射血分数(LVEF)低于预后良好组(P<0.05);单因素COX分析显示RV、LA、LVDd、LVEDV、LVESV、SV是扩张型心肌病患者预后不良的危险因素(P<0.05);多因素COX回归分析显示LVDd、LVESV、SV是扩张型心肌病患者预后不良的危险因素(P<0.05);ROC曲线分析显示:LVESV的曲线下面积值(AUC)最高为0.750(95%CI:0.659~0.828),联合后AUC为0.772(95%CI:0.682~0.847),敏感度显著提升;根据ROC分析所得截断值将扩张型心肌病患者进行分组,其中高LVDd组、低LVDd组总生存时间(OS)分别为(2.30±1.11)个月、(2.48±1.17)个月,高LVESV组、低LVESV组OS分别为(2.35±1.24)个月、(2.54±1.05)个月,高 SV 组、低 SV 组 OS 分别为(2.56±1.19)个月、(2.37±1.13)个月,Kap-lan-Meier生存分析结果显示各组OS在统计学上有显著差异(P<0.05).结论 心脏超声与MRI均可对扩张型心肌病患者预后进行评估,且临床可将MRI检测的LVESV、LVDd等指标作为参考以评估患者预后情况.
Objective To analyze the value of cardiac ultrasound and magnetic resonance imaging(MRI)in prognosis evaluation of dilated cardiomyopathy.Methods A total of 110 patients with dilated cardiomyopathy admitted to the hospi-tal from January 2020 to January 2023 were selected.All of them underwent cardiac ultrasound and MRI examinations.They were followed up and the prognosis was recorded.Cox regression analysis was performed to analyze the relationship between cardiac ultrasound and MRI parameters and the prognosis of dilated cardiomyopathy.Receiver operating characteristic(ROC)curves were used to analyze the value of the two in prognosis evaluation of dilated cardiomyopathy.Results A-mong the 110 patients,42 patients had endpoint events(poor prognosis group)and the remaining 68 patients without(good prognosis group).Right ventricular diameter(RV),left ventricular end systolic diameter(LVSd),left atrial diameter(LA)and left ventricular end diastolic diameter(LVDd)of the poor prognosis group were larger than those of the good prognosis group(P<0.05).Left ventricular end diastolic volume(LVEDV)and left ventricular end systolic volume(LVESV)of the poor prognosis group were larger than those of the good prognosis group.Stroke volume(SV)and left ven-tricular ejection fraction(LVEF)were lower than those of the good prognosis group(P<0.05).Univariate COX analysis found that RV,LA,LVDd,LVEDV,LVESV,and SV were risk factors for poor prognosis in patients with dilated cardiomyop-athy(P<0.05).Multivariate COX regression analysis found that LVDd,LVESV,and SV were risk factors for poor progno-sis in patients with dilated cardiomyopathy(P<0.05).ROC curves indicated that the area under the curve(AUC)of LVESV was the highest,which was 0.750(95%CI:0.659-0.828).The AUC of combination of indicators was 0.772(95%CI:0.682-0.847),and the sensitivity was significantly higher.According to cutoff values obtained from ROC anal-ysis,patients with dilated cardiomyopathy were grouped.Overall survival(OS)time of the large LVDd group and the small LVDd group was(2.30±1.11)months and(2.48±1.17)months.OS time of the large LVESV group and the small LVESV group was(2.35±1.24)months and(2.54±1.05)months.OS time of the large SV group and the small SV group was(2.56±1.19)months and(2.37±1.13)months.Kaplan-Meier survival analysis showed significant differences in OS between groups(P<0.05).Conclusion Both cardiac ultrasound and MRI can be used to evaluate the prognosis of patients with dilated cardiomyopathy.In clinical practice,indicators such as LVESV and LVDd detected by MRI can be used for evaluating the prognosis.

Dilated cardiomyopathyCardiac ultrasoundMagnetic resonance imagingPrognosis

焦方杰、黄蕾、赵白信、贾娟、浮志坤

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450000 郑州市第七人民医院超声科

450000 郑州市第七人民医院心血管外科

扩张型心肌病 心脏超声 磁共振成像 预后

2024

临床放射学杂志
黄石市医学科技情报所

临床放射学杂志

CSTPCD北大核心
影响因子:0.872
ISSN:1001-9324
年,卷(期):2024.43(12)