Objective To investigate the value of CT-based extracellular volume in the differential diagnosis of hepato-cellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC)and liver metastases.Methods The clinical and ima-ging data of 113 patients with pathologically diagnosed HCC,ICC,and liver metastases(49 HCC,33 ICC,and 31 liver me-tastases)who met the inclusion and exclusion criteria from January 2021 to August 2023 in Xinjiang Production and Con-struction Corps Hospital were retrospectively enrolled.The CT values of the liver parenchyma and the abdominal aorta at the same level within 1 cm of the lesion periphery and the delayed period were calculated.The values of fECV in each group and the level of ECV were statistically analyzed.Results There were statistically significant differences in the fECV values of lesions and liver parenchyma within 1 cm of the periphery of HCC group,ICC group and liver metastases group(P<0.05).There were statistically significant differences in the fECV values of liver parenchyma within 1 cm of the lesion periph-ery of the ICC group and the liver metastasis group,but there was no significant difference between the HCC group and the ICC group.Conclusion fECV based on CT delay period quantification can effectively diagnose and distinguish hepatocel-lular carcinoma,liver metastases and intrahepatic cholangiocarcinoma.